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clonazepam hydrochloride

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Identification
Molecular formula
C17H14Cl2N2O
CAS number
1622-62-4
IUPAC name
2-(2-chloro-6-oxo-11H-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium;chloride
State
State

At room temperature, clonazepam hydrochloride is in a solid state, specifically a crystalline powder.

Melting point (Celsius)
236.50
Melting point (Kelvin)
509.65
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
353.27g/mol
Molar mass
353.2710g/mol
Density
1.3200g/cm3
Appearence

Clonazepam hydrochloride appears as a white to off-white crystalline powder. It is typically odorless.

Comment on solubility

Solubility of 2-(2-chloro-6-oxo-11H-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium; chloride

This compound, known for its unique structure and functional groups, exhibits intriguing solubility properties that can be influenced by several factors. Specifically, its solubility in various solvents is typically characterized by the following:

  • Polarity: Being quaternary ammonium salt, it tends to be soluble in polar solvents such as water and lower alcohols.
  • Hydrogen Bonding: The presence of the ammonium group allows for potential hydrogen bonding, enhancing solubility in aqueous solutions.
  • pH Dependence: The solubility may vary with pH; it is generally more soluble in acidic conditions due to protonation effects.

It's important to note that the solubility of this compound can be greatly increased when:

  1. Incorporated into formulations that enhance dissolution.
  2. Used in conjunction with other solubilizing agents.

In conclusion, the solubility of 2-(2-chloro-6-oxo-11H-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium; chloride plays a pivotal role in its biological activity and application in medicinal chemistry. Understanding its solubility characteristics is essential for effective formulation and therapeutic use.

Interesting facts

Interesting Facts about 2-(2-Chloro-6-oxo-11H-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium Chloride

This fascinating compound falls within the family of benzodiazepines, which are widely recognized for their psychoactive properties. Here are some intriguing insights about this compound:

  • Structure and Functionality: The compound features a benzodiazepine framework, characterized by a *hinge region* that allows for flexibility in its interaction with biological receptors. This structural motif is key to its activity in the central nervous system.
  • Medical Applications: Compounds related to the benzodiazepine class, including this one, are known for their *anxiolytic* (anxiety-reducing), *sedative*, and *muscle relaxant* effects. As such, they have made a significant impact in clinical settings, particularly in managing anxiety disorders and insomnia.
  • Chlorine Atoms: The presence of chlorine in the structure contributes not just to its pharmacological profile but can also enhance *lipophilicity*, which may improve the ability of the compound to permeate biological membranes.
  • Dimethylamino Group: The dimethylamino moiety is known to influence the compound's *potency* and *selectivity* for various receptors, particularly GABAA receptors, making it an essential feature in its design.
  • Research Potential: Ongoing research into compounds like this one continues to unveil new therapeutic avenues. The exploration of derivatives helps in developing more targeted treatments with reduced side effects.

In summary, 2-(2-Chloro-6-oxo-11H-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium chloride embodies the intricate relationship between chemical structure and biological activity. As researchers continue to analyze such compounds, the future of pharmacology looks promising!

Synonyms
Clobenzepam hydrochloride
2726-03-6
618Q2FLB9R
Clobenzepam HCl
UNII-618Q2FLB9R
5,10-Dihydro-7-chloro-10-(2-(dimethylamino)ethyl)-11H-dibenzo(b,e)(1,4)diazepin-11-one HCl
11H-Dibenzo(b,e)(1,4)diazepin-11-one, 5,10-dihydro-7-chloro-10-(2-(dimethylamino)ethyl)-, hydrochloride