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Clonazepam

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Identification
Molecular formula
C15H11ClN2
CAS number
1622-61-3
IUPAC name
2-(2-chloro-6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine
State
State

At room temperature, Clonazepam is typically found in a solid state as a crystalline powder.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.15
Boiling point (Celsius)
468.50
Boiling point (Kelvin)
741.65
General information
Molecular weight
314.81g/mol
Molar mass
314.8080g/mol
Density
0.9240g/cm3
Appearence

The appearance of Clonazepam is typically in the form of small, powdery crystals or crystalline powder that is white or light yellow in color.

Comment on solubility

Solubility Characteristics

The compound 2-(2-chloro-6,11-dihydrobenzob[1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine exhibits unique solubility properties that are influenced by its complex structure. Understanding its solubility is crucial for various applications involving pharmaceuticals and chemical formulations.

Key Points on Solubility:

  • Polarity: The presence of chlorine and the amine functional group in the compound can enhance its polarity, which generally increases water solubility.
  • Solvents: This compound is likely to be soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO) due to its hydrophobic benzodiazepine core.
  • Temperature Dependence: Solubility may vary with temperature; typically, higher temperatures can lead to increased solubility for many organic compounds.
  • pH Sensitivity: The ionization of the amine group in varying pH conditions can significantly affect solubility, as basic conditions can enhance solubility by promoting ionization.

In summary, the solubility of this compound is a function of various factors such as polarity, the choice of solvent, temperature, and pH. As stated, "the interaction of functional groups plays a vital role in determining solubility." Understanding these dynamics can be pivotal in optimizing its use in scientific and industrial applications.

Interesting facts

Interesting Facts About 2-(2-chloro-6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine

The compound 2-(2-chloro-6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine is a fascinating substance with notable characteristics and implications in the field of medicinal chemistry. Here are some intriguing insights:

  • Therapeutic Potential: This compound is a derivative of benzodiazepines, which are well-known for their anxiolytic (anxiety-reducing) properties. Its structure suggests possible applications in treating anxiety, insomnia, and other psychological disorders.
  • Complex Structure: The chemical architecture of this compound features a bicyclic system, which contributes to its unique pharmacological profile. The incorporation of a chlorine atom introduces interesting electronic and steric effects that can influence its activity.
  • Research Significance: Studying variants of benzodiazepines, like this compound, aids scientists in understanding structure-activity relationships. These insights are crucial for enhancing efficacy and reducing side effects in new drugs.
  • Synthetic Pathways: Creating such complex molecules often involves intricate synthetic methods. Chemists employ various strategies, including multi-step synthesis and functional group transformations, to achieve the desired structure.
  • Safety and Regulation: As with many compounds in the benzodiazepine class, attention to dosage and administration is critical. Regulatory bodies closely monitor the use of such compounds due to the potential for dependence and side effects.

Conclusion

In summary, 2-(2-chloro-6,11-dihydrobenzo[b][1,4]benzodiazepin-5-yl)-N,N-dimethyl-ethanamine exemplifies the intersection of chemistry and pharmacology, highlighting both the potential benefits and challenges associated with pharmaceutical compounds. As research continues, compounds like this could play a significant role in advancing mental health treatment.

Synonyms
BRN 0894740
5H-Dibenzo(b,e)(1,4)diazepine, 10,11-dihydro-7-chloro-10-(2-(dimethylamino)ethyl)-
2244-74-8
DTXSID50176981
10,11-Dihydro-(5H)-dibenzo(b,e)(1,4)diazepine, 7-chloro-10-(2-(dimethylamino)ethyl)-
7-Chlor-10-beta-dimethylamino-aethyl-10,11-dihydro-5H-dibenzo-(b,e)(1,4)-diazepin [German]
7-Chlor-10-beta-dimethylamino-aethyl-10,11-dihydro-5H-dibenzo-(b,e)(1,4)-diazepin
DTXCID7099472
5-23-08-00274 (beilstein handbook reference)