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Desloratadine

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Identification
Molecular formula
C19H19ClN2O
CAS number
100643-71-8
IUPAC name
2-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine
State
State
Desloratadine is typically found in solid state at room temperature as it is a crystalline powder. It is commonly used in pharmaceutical formulations.
Melting point (Celsius)
156.00
Melting point (Kelvin)
429.20
Boiling point (Celsius)
526.00
Boiling point (Kelvin)
799.20
General information
Molecular weight
310.83g/mol
Molar mass
310.8260g/mol
Density
1.4200g/cm3
Appearence

Desloratadine appears as a white to pale yellow crystalline powder. It is not highly soluble in water but can dissolve in organic solvents such as ethanol and acetone.

Comment on solubility

Solubility Characteristics

The compound 2-[(2-chloro-7,8,9,10-tetrahydro-6H-cycloheptabquinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine presents an intriguing profile when it comes to its solubility.

Factors Influencing Solubility

Key factors that affect the solubility of this compound include:

  • Molecular Structure: The presence of the bulky and complex cyclic structure may hinder solubility in polar solvents.
  • Polar Functional Groups: The amino and ether functional groups contribute to the overall polarity, which can enhance solubility in suitable solvents.
  • Chlorine Atom: The electronegative chlorine atom may impact solubility characteristics by increasing intermolecular interactions.

Solvent Compatibility

Due to its unique structure, the solubility of this compound can vary significantly depending on the solvent used. It is anticipated to be:

  • Moderately soluble in organic solvents such as ethanol and methanol.
  • Less soluble in volatile hydrocarbons due to steric hindrance.
  • Potentially insoluble in water, as the large hydrophobic regions can limit interaction with water molecules.

In conclusion, while predicting the precise solubility requires empirical data, one can hypothesize that the combination of polarity from functional groups and hydrophobic characteristics from the cyclic structure leads to intricate solubility behavior. Understanding these properties is crucial for applications in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 2-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine

This compound, frequently referred to as an advanced synthetic molecule, is captivating due to its unique structural characteristics and potential applications in medicinal chemistry. Here are some intriguing facts:

  • Pharmacological Potential: The structure features a tetrahydro-cycloheptacquinoline moiety, which suggests interesting biological activities. Compounds with similar frameworks have been studied for their role as potential therapeutic agents.
  • Chirality and Stereochemistry: The presence of multiple chiral centers within the compound can lead to stereoisomers, significantly influencing the pharmacodynamics and pharmacokinetics of the compound. This aspect is crucial in drug development, as different enantiomers can exhibit vastly different biological activities.
  • Role of Chlorine Substitution: The chlorinated moiety serves not only as a point of substitution but also enhances lipid solubility, thereby allowing the compound to penetrate cellular membranes more effectively. This can potentially augment its bioavailability.
  • Targeting CNS Disorders: The unique structure is hypothesized to interact with the central nervous system (CNS) due to the presence of fused rings, making it an interesting candidate for the exploration of treatments for disorders like depression or anxiety.
  • Cross-Disciplinary Research: This compound exemplifies the intersection of organic chemistry, pharmacology, and toxicology, making it a subject of interdisciplinary interest. Researchers from various fields may come together to investigate its properties and potential applications.

To encapsulate its significance, it's essential to note that scientific exploration of compounds like this one can lead to breakthroughs in therapeutics and enhance our understanding of chemical interactions in biological systems.