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2-(2-chloroethyl)-3,4-dihydroisoquinoline

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Identification
Molecular formula
C11H12ClN
CAS number
65417-00-5
IUPAC name
2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline
State
State

At room temperature, 2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline is in a liquid state.

Melting point (Celsius)
-22.00
Melting point (Kelvin)
251.15
Boiling point (Celsius)
275.10
Boiling point (Kelvin)
548.25
General information
Molecular weight
181.67g/mol
Molar mass
181.6650g/mol
Density
1.1197g/cm3
Appearence

The compound 2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline typically appears as a colorless to pale yellow liquid. It may exhibit a characteristic aromatic odor due to its isoquinoline moiety.

Comment on solubility

Solubility of 2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline

The solubility of 2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline can be characterized by several important factors that influence its behavior in different solvents:

  • Solvent Polarity: This compound's solubility can vary significantly in polar and non-polar solvents. Generally, compounds with a more hydrophobic structure tend to be more soluble in organic solvents such as ethanol or chloroform rather than in water.
  • Temperature: Increasing temperatures may improve solubility as it often enhances molecular interactions and kinetic activity.
  • Functional Groups: The presence of the chloroethyl group suggests the potential for some polar interactions, which may affect its solubility profile in different media.
  • Concentration Effects: At higher concentrations, solubility limits can be reached, leading to precipitation; it's important to consider the saturation points in various solvents.

Despite these factors, the overall solubility of 2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline would generally classify it as having low to moderate solubility in aqueous environments. Such characteristics make it potentially useful in applications where organic solvent systems are preferred.

In summary, understanding the solubility of this compound is crucial for practical applications in fields such as pharmaceuticals, where solvent interactions can significantly influence efficacy and behavior in biological systems.

Interesting facts

Interesting Facts about 2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline

2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline is a fascinating compound that showcases the intricacies of organic chemistry and medicinal applications. Here are some notable aspects:

  • Structural Variety: This compound belongs to the class of isoquinolines, which are a significant structural motif in various natural products and pharmaceuticals.
  • Biological Activity: Isoquinolines and their derivatives have been extensively studied for their biological activities, including roles as:
    • Anticancer agents
    • Antimicrobial compounds
    • Antidepressants
  • Chloroethyl Group: The presence of the chloroethyl group enhances the reactivity of the compound, making it a potential precursor for various synthetic transformations, including the formation of more complex molecules.
  • Synthetic Routes: The synthesis of this compound often involves multi-step organic reactions. The formation of isoquinoline is particularly of interest due to its various synthetic strategies, such as:
    • Cyclization reactions
    • Condensation reactions
    • Electrophilic substitutions
  • Research Potential: Due to the unique functionality of this compound, ongoing research may uncover new therapeutic avenues and applications in drug design. As quoted by chemist John R. Harris, "Every molecule holds a story, waiting to be uncovered."

In summary, 2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline not only exemplifies an important chemical structure but also serves as a reminder of the vast potential inherent in the world of organic compounds.

Synonyms
2-(2-chloroethyl)-3,4-dihydro-1H-isoquinoline
68085-34-7
2-(2-chloroethyl)-1,2,3,4-tetrahydroisoquinoline
SCHEMBL24098519
SCHEMBL30362966
AKOS010539872
CS-0364389