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Lidocaine

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Identification
Molecular formula
C14H22ClN2O
CAS number
137-58-6
IUPAC name
2-[2-chloroethyl(methyl)amino]-N-(2,6-dimethylphenyl)acetamide
State
State

Lidocaine is commonly found as a solid at room temperature. Its solid form is usually a crystalline powder, which can be formulated into various pharmaceutical products, like gels and solutions for medical use.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.80
General information
Molecular weight
234.34g/mol
Molar mass
234.3420g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is a white, crystalline powder. It is odorless and has a slightly bitter taste. The powder is often used in its hydrochloride salt form, which is also white and crystalline in nature. It is soluble in water and alcohols, making it versatile for different formulations, especially in medical applications.

Comment on solubility

Solubility of 2-[2-chloroethyl(methyl)amino]-N-(2,6-dimethylphenyl)acetamide

The solubility of the compound 2-[2-chloroethyl(methyl)amino]-N-(2,6-dimethylphenyl)acetamide can be quite complex due to its unique structure. This compound exhibits characteristics that influence its solubility in various solvents:

  • Polarity: The presence of the amino group and the chloride atom generally increases polarity, suggesting better solubility in polar solvents like water.
  • Hydrophobic character: The hydrocarbon portion, especially with the 2,6-dimethylphenyl group, introduces a hydrophobic aspect, which may limit solubility in highly polar solvents.
  • Amphipathic nature: This compound can exhibit amphipathic behavior, making it soluble in both polar and non-polar solvents to some degree.

In practical terms, one might find that:

  1. The compound readily dissolves in organic solvents such as methanol, dimethyl sulfoxide (DMSO), and acetone.
  2. It may show limited solubility in pure water, but can dissolve better in aqueous solutions with added cosolvents or surfactants.

To summarize, the solubility of 2-[2-chloroethyl(methyl)amino]-N-(2,6-dimethylphenyl)acetamide will largely depend on the solvent properties and the concentrations used. Understanding these factors is essential for practical applications of this compound.

Interesting facts

Interesting Facts about 2-[2-chloroethyl(methyl)amino]-N-(2,6-dimethylphenyl)acetamide

This fascinating compound, often known in scientific circles for its intricate structure and potential applications, represents a unique blend of chemistry and pharmacology. Here are some intriguing insights:

  • Pharmaceutical Relevance: This compound is primarily explored for its potential as a therapeutic agent. Its structural features allow it to interact with biological systems, making it a candidate for drug development.
  • Complex Functionality: The presence of the chloroethyl moiety introduces interesting reactivity patterns, which may facilitate targeted delivery into cells or tissues, potentially enhancing its effectiveness in medical applications.
  • Substituent Variability: The 2,6-dimethylphenyl group contributes to its lipophilicity, influencing how the compound behaves in biological systems. This is vital for understanding absorption, distribution, metabolism, and excretion (ADME) profiles.
  • Mechanism of Action: The compound may operate through diverse mechanisms in vivo, such as acting on neurotransmitter receptors or enzymes, which is an important focus of ongoing research.
  • Analytical Techniques: Researchers often utilize mass spectrometry and NMR spectroscopy to analyze the behavior and properties of this compound, helping to elucidate its structure-function relationship.

As scientists continue to explore the myriad applications of this compound, its unique characteristics and potential implications in treating various conditions make it a subject of great interest in the field of medicinal chemistry.

Synonyms
23562-35-8
BRN 2379156
Acetamide, 2-((2-chloroethyl)methylamino)-N-(2,6-dimethylphenyl)-
N-((2-Chloroethyl)-N-methylamino)aceto-2,6-xylidide
DTXSID80178155
2',6'-ACETOXYLIDIDE, 2-((2-CHLOROETHYL)METHYLAMINO)-
RefChem:314338
DTXCID10100646
Acetamide, 2-((2-chloroethyl)methylamino)-N-(2,6-dimethylphenyl)-(9CI)
Acetamide, 2-((2-chloroethyl)methylamino)-N-(2,6-dimethylphenyl)- (9CI)