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Fenclofenac

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Identification
Molecular formula
C14H11ClO3
CAS number
93-49-2
IUPAC name
2-(2-chlorophenoxy)-2-phenyl-acetic acid
State
State

At room temperature, Fenclofenac is in a solid state, characterized by its crystalline appearance.

Melting point (Celsius)
161.00
Melting point (Kelvin)
434.00
Boiling point (Celsius)
488.70
Boiling point (Kelvin)
761.85
General information
Molecular weight
262.69g/mol
Molar mass
262.6910g/mol
Density
1.3317g/cm3
Appearence

Fenclofenac appears as a white to off-white crystalline solid. It is initially odorless.

Comment on solubility

Solubility of 2-(2-chlorophenoxy)-2-phenyl-acetic acid

2-(2-chlorophenoxy)-2-phenyl-acetic acid, commonly referred to as a phenoxyacetic acid derivative, displays notable characteristics regarding its solubility:

  • Solvent System: This compound is primarily soluble in organic solvents such as ethanol and acetone. The aromatic structures contribute to its compatibility with non-polar solvents.
  • Water Solubility: Limited water solubility is observed due to the large hydrophobic phenyl and chlorophenyl moieties, which hinder its interaction with water molecules.
  • pH Dependency: The presence of the carboxylic acid group can alter solubility depending on the pH of the solution. At higher pH levels, the deprotonation of the carboxylic acid may lead to increased water solubility due to the formation of anionic species.

In summary, while 2-(2-chlorophenoxy)-2-phenyl-acetic acid is soluble in non-polar organic solvents, its limited water solubility and pH-dependent behavior illustrate the complexity of its interactions in different solvent environments. The potential applications in formulations can often dictate the choice of solvent based on these solubility characteristics, making it essential for chemists to consider these factors.

Interesting facts

Interesting Facts about 2-(2-Chlorophenoxy)-2-phenyl-acetic Acid

2-(2-Chlorophenoxy)-2-phenyl-acetic acid, often abbreviated as clotiazepam, is a fascinating compound in the realm of organic chemistry. Here are some engaging insights:

  • Pharmaceutical Applications: This compound is known for its role as a precursor in the synthesis of various pharmaceuticals, particularly in the development of anti-inflammatory and analgesic medications.
  • Mechanism of Action: While the specific mechanism of 2-(2-chlorophenoxy)-2-phenyl-acetic acid may vary, compounds within this class often function by inhibiting certain enzymes or pathways involved in inflammatory responses, showcasing the intricate connections between organic compounds and biological systems.
  • Structure-Activity Relationship (SAR): The presence of the chlorine atom and the phenoxy group in its structure significantly influences the compound's potency and pharmacological properties. Scientists often study these relationships critically to design better therapeutic agents.
  • Environmental Considerations: As with many organic compounds, understanding the environmental impact and degradation pathways of 2-(2-chlorophenoxy)-2-phenyl-acetic acid is crucial in evaluating its safety and sustainability during its production and use.
  • Research Potential: Ongoing research is exploring derivatives of this acid, aiming to enhance its efficacy or reduce side effects, demonstrating how a single compound can lead to a plethora of research opportunities in medicinal chemistry.

As a dynamic compound with diverse applications, 2-(2-chlorophenoxy)-2-phenyl-acetic acid exemplifies the intersection of chemistry and pharmacology, emphasizing the essential role that chemical compounds play in advancing medical science. Its kind of structural modifications could lead to breakthroughs in drug development, proving that chemistry is not just an academic discipline, but a gateway to innovative solutions for real-world challenges.

Synonyms
(o-Chlorophenoxy)phenylacetic acid
2-(2-chlorophenoxy)-2-phenylacetic acid
17639-01-9
Benzeneacetic acid, alpha-(2-chlorophenoxy)-
(2-chlorophenoxy)(phenyl)acetic acid
BRN 2587760
ACETIC ACID, (o-CHLOROPHENOXY)PHENYL-
Acide (o-chlorophenoxy)phenylacetique [French]
Acide (o-chlorophenoxy)phenylacetique
SCHEMBL11794321
DTXSID40938792
SBB076873
STL220228
AKOS000165093
AKOS016050738
ST45244025
A1-64278