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Ketamine

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Identification
Molecular formula
C13H16ClNO
CAS number
6740-88-1
IUPAC name
2-(2-chlorophenyl)-2-(methylamino)cyclohexanone
State
State

Ketamine is typically in a solid state at room temperature when in its pure form as a crystalline powder. However, it is commonly distributed as a liquid in pharmaceutical settings for injection purposes.

Melting point (Celsius)
93.50
Melting point (Kelvin)
366.70
Boiling point (Celsius)
274.70
Boiling point (Kelvin)
547.90
General information
Molecular weight
237.73g/mol
Molar mass
237.7260g/mol
Density
1.0450g/cm3
Appearence

Ketamine typically appears as a white crystalline powder or clear liquid when prepared for medical use. It is often supplied in vials as a liquid for intravenous or intramuscular injection. When in powder form, it may appear slightly off-white depending on purity and form of synthesis.

Comment on solubility

Solubility of 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone (C13H16ClNO)

The solubility profile of 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone is quite intriguing and can vary based on several factors. Generally speaking, this compound exhibits:

  • Moderate solubility in organic solvents: The presence of the chlorophenyl group and the methylamino group often allows for good solvation in nonpolar to moderately polar organic solvents.
  • Poor solubility in water: The bulky cyclohexanone structure combined with hydrophobic components typically results in limited solubility in aqueous environments.
  • Temperature dependence: The solubility may increase with temperature, making it crucial to consider the thermal conditions of usage.

According to some studies, it is emphasized that:

"Solubility is a critical factor influencing bioavailability and overall chemical behavior in different environments."

In practical applications, understanding the solubility characteristics is essential for formulating effective compounds, especially in pharmaceutical contexts where solvent selection can dictate the success of a drug formulation.


Interesting facts

Interesting Facts about 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone

2-(2-chlorophenyl)-2-(methylamino)cyclohexanone is a fascinating compound that has garnered attention for its unique structure and potential applications. Here are some intriguing facts about this compound:

  • Pharmacological Interest: This compound is a member of a class of drugs known for their psychoactive effects. Researchers often explore its potential as an antidepressant and its mechanisms of action within the central nervous system.
  • Chlorophenyl Group: The presence of the chloro group (Cl) on the phenyl ring significantly influences the compound's biochemical properties, allowing it to interact differently with various biological targets.
  • Stereochemistry: The cyclohexanone backbone introduces interesting stereochemical elements that may impact the compound's activity. Understanding these elements can help chemists design more effective derivatives.
  • Analytical Techniques: A variety of analytical methods, such as NMR spectroscopy and mass spectrometry, can be applied to study this compound's structure and behavior, providing insights into its properties and potential use.
  • Historical Context: Compounds with similar structures have a rich history in medicinal chemistry, often paving the way for new therapeutic discoveries. Their study showcases the ongoing evolution of pharmaceutical science.

In summary, 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone is not only a chemically intriguing molecule but also a compound that opens up pathways for therapeutic exploration and scientific inquiry. Its structural nuances and interactions highlight the importance of continued research in the field of organic chemistry.

Synonyms
ketamine
dl-Ketamine
Ketaject
Special K
Ketalar
(+-)-Ketamine
CI 581 base
Calypsol
Ketaminum
6740-88-1
CLSTA 20
(+/-)-Ketamine
narketan
Cetamina
Ketanest
Tekam
Ketalar base
ketamina
2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
Ursotamin
KETAMINE HCL
Anaket v
Ketaminum [INN-Latin]
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone
Cetamina [INN-Spanish]
Special K [street name]
Clorketam 1000
Ketasol 100
Imalgene 1000
NSC 70151
Vetaket
EINECS 229-804-1
NSC-70151
Ketamine (INN)
UNII-690G0D6V8H
BRN 2216965
CHEBI:6121
100477-72-3
DTXSID8023187
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-
HSDB 2180
690G0D6V8H
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
CHEMBL742
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
DTXCID703187
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)-
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+-)-
KETAFOL COMPONENT KETAMINE
PMI-150
EC 229-804-1
2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
Ketamine-d4
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-
DEA No. 7285
NCGC00159480-02
NCGC00159480-03
Ketaminum (INN-Latin)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+/-)-
KETAMINE [INN]
Cetamina (INN-Spanish)
Ketamine Base
Special K (street name)
Ketamine [INN:BAN]
Ketoject
CAS-6740-88-1
Tekam (TN)
Ketaminum (Latin)
Ketolar (Salt/Mix)
Vetalar (Salt/Mix)
1246911-76-1
Kalipsol (Salt/Mix)
Ketanest (Salt/Mix)
KETAMINE [HSDB]
KETAMINE [MI]
KETAMINE [VANDF]
(.+/-.)-Ketamine
KETAMINE [WHO-DD]
Cyclohexanone, (.+-.)-
SCHEMBL16103
MLS001331674
DivK1c_000217
GTPL4233
(+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
SCHEMBL17084881
KBio1_000217
N01AX03
NINDS_000217
HMS2272G05
IBA64349
NSC70151
Tox21_111703
Tox21_111704
BDBM50044140
DB01221
IDI1_000217
SMR000238141
NS00000409
NS00116228
C07525
D08098
Q243547
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone #
(.+/-.)-2-(O-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone(Ketamine)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9CI)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (.+/-.)-
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (.+/-.)-
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8CI)
229-804-1