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Ketamine hydrochloride

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Identification
Molecular formula
C13H17Cl2NO
CAS number
1867-66-9
IUPAC name
2-(2-chlorophenyl)-2-(methylamino)cyclohexanone;hydrochloride
State
State
Ketamine hydrochloride is typically in the solid state at room temperature. It is often used in a stable salt form, making it suitable for pharmaceutical applications and research.
Melting point (Celsius)
266.00
Melting point (Kelvin)
539.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
274.19g/mol
Molar mass
274.1930g/mol
Density
1.1260g/cm3
Appearence
Ketamine hydrochloride appears as a white crystalline powder. It is odorless and highly soluble in water, allowing for easy administration in various forms. Its crystalline nature gives it a slightly shiny appearance under light.
Comment on solubility

Solubility of 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone;hydrochloride

The solubility of 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone; hydrochloride is a vital characteristic that affects its utility in various applications. Here are some key points to consider:

  • Hydrochloride Form: As a hydrochloride salt, this compound generally exhibits improved solubility in polar solvents compared to its base form.
  • Polar Solvents: It is likely to be soluble in water and other polar solvents due to the presence of the hydrochloride group, which increases ionic interactions.
  • Solvent pH Influence: The solubility may also be affected by the pH of the solution. In acidic conditions, the compound remains in its soluble form, while alkaline conditions might precipitate the base.
  • Temperature Effects: The solubility tends to increase with temperature, making heating a useful technique to dissolve the compound efficiently.

In summary, the solubility of 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone; hydrochloride is primarily enhanced by its hydrochloride form, polar characteristics, and external conditions, such as solvent pH and temperature. Understanding these factors is crucial for its effective use in chemical processes and therapeutics.

Interesting facts

Interesting Facts About 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone;hydrochloride

This compound is a fascinating example of a substituted cyclohexanone that exhibits a unique blend of properties due to its structural features. Primarily known for its role in pharmacological research, it has attracted attention in various scientific studies. Here are a few captivating aspects to consider:

  • Pharmacological Relevance: This compound is known to act on the nervous system, potentially affecting neurotransmitter pathways.
  • Structural Intrigue: The presence of a chlorophenyl group enhances its lipophilicity, which is essential for pharmacodynamics, allowing it to cross biological membranes effectively.
  • Research Applications: Due to its complex structure, researchers often study analogs of this compound for therapeutic potential in treating various disorders, particularly in the fields of psychology and psychiatry.
  • Historical Significance: The exploration of cyclohexanones in medicinal chemistry has roots in the search for safer and more effective psychoactive substances, emphasizing the compound's importance in drug development.
  • Safety and Regulation: Like many compounds with pharmacological activity, it is subject to strict regulation, and understanding its effects requires careful study to mitigate any risks associated with usage.

Insights from Chemistry Students

Many chemistry students find exploring compounds like this to be an enriching experience. Here are some insights they gather:

  • Complex Logic: Studying such compounds helps in understanding structure-activity relationships, which is a key concept in medicinal chemistry.
  • Interdisciplinary Connections: It bridges chemistry with medicine, making it a prime topic for interdisciplinary research discussions.
  • Methodological Skills: Synthesis and analysis of such compounds provide hands-on experience with various techniques, enhancing laboratory skills.

In summary, 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone; hydrochloride embodies a wealth of knowledge for both seasoned chemists and aspiring students, demonstrating the intricate dance between structure and activity in the world of pharmaceutical sciences.

Synonyms
KETAMINE HYDROCHLORIDE
1867-66-9
Vetalar
Kalipsol
Ketavet
Ketolar
KETAMINE HCL
Ketamine chloride
Ketavet 100
2-(2-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
CL 369
(+-)-Ketamine hydrochloride
CN-52,372-2
Ketamine hydrochloride ciii
Ketamine (as hydrochloride)
EINECS 217-484-6
UNII-O18YUO0I83
O18YUO0I83
CL-369
(+-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
CN-523722
CN-52372-2
DTXSID4040137
CHEBI:650657
EC 217-484-6
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, hydrochloride
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, hydrochloride, (+-)-
Ketamine hydrochloride [USAN:USP:JAN]
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, hydrochloride, (+-)-
KETAMINE HYDROCHLORIDE (MART.)
KETAMINE HYDROCHLORIDE [MART.]
CYCLOHEXANONE, 2-(2-CHLOROPHENYL)-2-(METHYLAMINO)-, HYDROCHLORIDE (1:1)
Ketamine hydrochloride (USAN:USP:JAN)
KETAMINE HYDROCHLORIDE (EP IMPURITY)
KETAMINE HYDROCHLORIDE [EP IMPURITY]
KETAMINE HYDROCHLORIDE (EP MONOGRAPH)
KETAMINE HYDROCHLORIDE [EP MONOGRAPH]
KETAMINE HYDROCHLORIDE CIII (USP-RS)
KETAMINE HYDROCHLORIDE CIII [USP-RS]
KETAMINE HYDROCHLORIDE (USP MONOGRAPH)
KETAMINE HYDROCHLORIDE [USP MONOGRAPH]
Zetamine
Ketaset, Vetalar
1-(2-chlorophenyl)-N-methyl-2-oxocyclohexanaminium chloride
2-(o-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
KETATHESIA
Ketamine Hydrochloride Injection
DTXCID2020137
Ketamine Hydrochloride Injection, USP
(2RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone monohydrochloride
217-484-6
Ketaset
Ketalar
Ketanest
CI-581
Ketamine.HCl
Calipsol
DEA No. 7285
Ketavet (Veterinary)
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride
CI 581
Ketamine Hydrochloride (1.0 mg/mL in Methanol)
(R)-(-)-Ketamine hydrochloride
Ketalar (TN)
Ketamini hydrochloridum
CHEMBL1714
SCHEMBL26999
KETAMINE HYDROCHLORIDE [MI]
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride
BCP25943
IBA79524
Ketamine hydrochloride (JP18/USP)
KETAMINE HYDROCHLORIDE [JAN]
KETAMINE HYDROCHLORIDE [USAN]
NSC116131
(+/-)-Ketamine hydrochloride, solid
KETAMINE HYDROCHLORIDE [VANDF]
AKOS005287313
AB02117
KETAMINE HYDROCHLORIDE [WHO-DD]
KETAMINE HYDROCHLORIDE [WHO-IP]
NSC-116131
KETAMINE HYDROCHLORIDE [GREEN BOOK]
DB-044614
DB-048467
KETAMINE HYDROCHLORIDE [ORANGE BOOK]
NS00076304
KETAMINI HYDROCHLORIDUM [WHO-IP LATIN]
C07843
D00711
A813079
Ketamine.HCl, 1mg/ml in Methanol (as free base)
Q-201266
Q27105184
Ketamine Hydrochloride 1.0 mg/ml in Methanol (as free base)
2-(2-chlorophenyl)-2-(methylamino)-1-cyclohexanone hydrochloride
(+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Ketamine hydrochloride, European Pharmacopoeia (EP) Reference Standard
CYCLOHEXANONE, 2-(O-CHLOROPHENYL)-2-(METHYLAMINO)-, HYDROCHLORIDE, (+/-)-
KETAMINE (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride