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(±)-2-(2-chlorophenyl)acetic acid

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Identification
Molecular formula
C8H7ClO2
CAS number
2444-40-8
IUPAC name
2-(2-chlorophenyl)acetic acid
State
State
Solid at room temperature.
Melting point (Celsius)
93.00
Melting point (Kelvin)
366.00
Boiling point (Celsius)
258.00
Boiling point (Kelvin)
531.00
General information
Molecular weight
170.59g/mol
Molar mass
170.5790g/mol
Density
1.3080g/cm3
Appearence

The compound appears as a white crystalline solid.

Comment on solubility

Solubility of 2-(2-chlorophenyl)acetic acid

2-(2-chlorophenyl)acetic acid, with its unique structure, exhibits notable solubility characteristics that are important to understand for its applications in various fields. Here are some key points regarding its solubility:

  • Solvent Interaction: This compound is moderately soluble in polar solvents like water due to its carboxylic acid group, which can form hydrogen bonds.
  • Solubility in Organic Solvents: It tends to be more soluble in non-polar organic solvents — like ethanol and ether — where it can effectively interact through Van der Waals forces.
  • Temperature Dependency: Solubility can increase with temperature, making it more effective for certain applications when heated.
  • Concentration Effects: As its concentration in solution increases, there may be a tendency towards decreased solubility due to solute-solute interactions.

Understanding the solubility of 2-(2-chlorophenyl)acetic acid is crucial, as it impacts its bioavailability and effectiveness in various chemical processes. As stated, "solubility is the key to reactivity," highlighting its importance in the field of chemistry.

Interesting facts

Interesting Facts about 2-(2-Chlorophenyl)acetic Acid

2-(2-Chlorophenyl)acetic acid, often abbreviated as 2-CPA, is a fascinating organic compound with applications in various fields. Here are some intriguing insights into this chemical:

  • Pharmaceutical Significance: 2-CPA has been studied for its potential role in medicinal chemistry, particularly as a precursor in the synthesis of anti-inflammatory and analgesic agents.
  • Structure-Activity Relationship: The presence of the chlorophenyl group enhances the compound's biological activity, making it a subject of interest in drug design and development.
  • Mechanism of Action: Research indicates that compounds like 2-CPA may interact with enzymes and receptors in the body, contributing to their effects on pain and inflammation.
  • Synthesis: The synthetic pathways of 2-CPA often involve straightforward reactions such as acylation and chlorination, making it accessible for laboratory studies.
  • Environmental Considerations: As with many chlorinated compounds, the environmental impact of 2-CPA is a topic of study, particularly regarding its persistence in biological systems.

In the world of chemistry, 2-(2-chlorophenyl)acetic acid serves as a reminder of how slight modifications in chemical structure can significantly impact biological activity and therapeutic potential. As the famed chemist, Linus Pauling, once said, "The structure of a compound determines its properties." This principle is vividly illustrated in the case of 2-CPA.

As research continues, our understanding of 2-CPA and its derivatives may lead to improved therapeutic options, showcasing the ever-evolving connection between chemistry and health.

Synonyms
2-CHLOROPHENYLACETIC ACID
2444-36-2
o-Chlorophenylacetic acid
(2-Chlorophenyl)acetic acid
Benzeneacetic acid, 2-chloro-
(o-Chlorophenyl)acetic acid
Acetic acid, (o-chlorophenyl)-
NSC 4613
7BF49L8BR5
CCRIS 8621
NSC-4613
EINECS 219-482-0
AI3-20877
DTXSID50179194
DTXCID80101685
Benzeneacetic acid, 2-chloro-(9CI)
Acetic acid, (o-chlorophenyl)-(8CI)
219-482-0
inchi=1/c8h7clo2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4h,5h2,(h,10,11
2-(2-chlorophenyl)acetic acid
2-Chlorophenylaceticacid
MFCD00004317
2-chlorobenzeneacetic acid
o-chlorophenyl acetic acid
2-chloro-benzeneacetic acid
(2-Chlorophenyl)acetic Acid; (o-Chlorophenyl)acetic Acid; 2-(o-Chlorophenyl)ethanoic Acid; 2-Chlorobenzeneacetic Acid; NSC 4613; o-Chlorobenzeneacetic Acid
chlorobenzene-acetic acid
o-chlorophenyl-acetic acid
UNII-7BF49L8BR5
(2-chlorophenyl) acetic acid
(2-chlorophenyl)-acetic acid
SCHEMBL194831
(2-chloro-phenyl)-acetic acid
2-Chlorophenylacetic acid, 99%
BDBM16424
NSC4613
STR02235
STK428920
AKOS000120650
BS-3930
CS-W020113
FC38601
SY002858
A5034
NS00027660
EN300-17291
D87878
Q63408948
Z56911957
F2191-0042