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Clomiphene

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Identification
Molecular formula
C13H19ClN2
CAS number
50-41-9
IUPAC name
2-[(2-chlorophenyl)methyl]-1,1-dimethyl-guanidine
State
State

At room temperature, clomiphene exists as a solid. It must be stored in a cool, dry place to maintain its stability and efficacy.

Melting point (Celsius)
116.00
Melting point (Kelvin)
389.15
Boiling point (Celsius)
103.00
Boiling point (Kelvin)
376.15
General information
Molecular weight
255.76g/mol
Molar mass
299.8120g/mol
Density
1.0516g/cm3
Appearence

Clomiphene is typically found as a white to pale yellow, crystalline powder. Its crystalline nature means it can often reflect light, giving it a slightly shiny appearance. It is odorless and typically used in pharmaceutical applications.

Comment on solubility

Solubility of 2-[(2-chlorophenyl)methyl]-1,1-dimethyl-guanidine

The solubility of 2-[(2-chlorophenyl)methyl]-1,1-dimethyl-guanidine can be quite intriguing. This compound's solubility profile is influenced by several factors, including:

  • Polarity: The presence of the 2-chlorophenyl group suggests a degree of polarity, which can enhance solubility in polar solvents like water.
  • Functional Groups: Guanidines are known to exhibit good solubility in water due to their ability to form hydrogen bonds. Thus, this compound is likely to be soluble in aqueous solutions.
  • Solvent Compatibility: In addition to water, 2-[(2-chlorophenyl)methyl]-1,1-dimethyl-guanidine may also be soluble in various organic solvents, such as dimethyl sulfoxide (DMSO) and ethanol, owing to its less polar characteristics.
  • Temperature Dependence: As with many compounds, the solubility may vary with temperature; generally, an increase in temperature often leads to higher solubility for solid compounds.

It is essential to note that while the compound is likely soluble in both polar and some nonpolar solvents, precise solubility values can vary based on specific conditions and concentrations. Therefore, experimental validation is key!

Interesting facts

Interesting Facts about 2-[(2-chlorophenyl)methyl]-1,1-dimethyl-guanidine

2-[(2-chlorophenyl)methyl]-1,1-dimethyl-guanidine, often abbreviated as DCMG, is a fascinating compound primarily recognized for its applications in medicinal chemistry. Here are some key aspects to consider:

  • Pharmacological Interest: This compound has been of considerable interest due to its potential pharmacological activities, particularly as a selective GABAA receptor modulator. The guanidine moiety allows interactions with neurotransmitter systems, which is a significant area of research in neuropharmacology.
  • Structure and Function: The incorporation of a 2-chlorophenyl group increases the lipophilicity of the molecule, enhancing its ability to cross biological membranes, which is critical for its efficacy as a drug candidate.
  • Research Applications: Studies on DCMG contribute to the understanding of various processes, including neurotransmission and synaptic plasticity, which are fundamental for brain function and may provide insights into treating neurological disorders.
  • Environmental Impact: Although primarily studied for therapeutic applications, the environmental chemistry of similar guanidine derivatives poses questions about their behavior and stability in different ecosystems.

Furthermore, as aptly stated in the literature, "the design of compound structure is key to unlocking therapeutic potential." The intricate balance of structure and function in compounds like DCMG underscores the importance of synthetic chemistry in advancing medical science.

Overall, 2-[(2-chlorophenyl)methyl]-1,1-dimethyl-guanidine serves as a compelling example of how organic compounds can hold the keys to understanding complex biological systems and developing new therapeutic agents.

Synonyms
N''-[(2-Chlorophenyl)methyl]-N,N-dimethylguanidine
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