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Clonidine

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Identification
Molecular formula
C9H10ClN3
CAS number
4205-91-8
IUPAC name
2-[(2-chlorophenyl)methyl]guanidine
State
State

At room temperature, Clonidine is in a solid state.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
419.00
Boiling point (Kelvin)
692.15
General information
Molecular weight
191.65g/mol
Molar mass
191.6500g/mol
Density
1.4396g/cm3
Appearence

Clonidine presents as a white crystalline powder. It is often described as having a characteristic appearance that facilitates its identification in laboratory and industrial settings.

Comment on solubility

Solubility of 2-[(2-chlorophenyl)methyl]guanidine

The solubility of 2-[(2-chlorophenyl)methyl]guanidine can be considered influenced by several factors including its molecular structure, interactions with solvents, and temperature. Generally, this compound is known to be:

  • Moderately soluble in polar solvents such as water due to the presence of guanidine functional group.
  • More soluble in organic solvents like ethanol and methanol where non-polar characteristics can facilitate interaction.
  • Less soluble in non-polar solvents, indicating that its solubility is greatly affected by the solvent's polarity.

The reason for these behaviors lies in the hydrophilic nature of the guanidine moiety, which can form hydrogen bonds with water, counteracted by the hydrophobic 2-chlorophenyl group. It is crucial to note that:

  1. Temperature can significantly affect solubility; generally, increased temperature can lead to higher solubility.
  2. The pH of the solution might also alter solubility, as guanidines can undergo protonation, affecting their interactions with solvents.

In summary, while 2-[(2-chlorophenyl)methyl]guanidine demonstrates certain solubility properties, prediction of solubility requires consideration of specific environmental conditions, including temperature and solvent characteristics. Thus, understanding these factors is key to effectively utilizing this compound in practical applications.

Interesting facts

Interesting Facts about 2-[(2-chlorophenyl)methyl]guanidine

2-[(2-chlorophenyl)methyl]guanidine is a fascinating compound with various implications in both scientific research and potential therapeutic applications. Here are some intriguing aspects of this compound:

  • Biological Activity: This compound is often studied for its biological properties, particularly in relation to its effects on certain receptor systems in the body. Research has indicated that it may exhibit anti-inflammatory and potential anticancer activities, making it a candidate for further investigation in pharmacology.
  • Synthesis: The synthesis of 2-[(2-chlorophenyl)methyl]guanidine typically involves multi-step reactions that require a keen understanding of organic chemistry principles. Its complexity provides students with a rich learning experience in synthetic methods and techniques.
  • Mechanism of Action: The compound's mechanism of action, particularly on how it binds to biological targets, presents an exciting area of study. Understanding these interactions may open doors to designing more effective derivatives with enhanced efficacy and reduced side effects.
  • Structure-Activity Relationship: The presence of a chlorine atom on the aromatic ring leads to unique electronic properties. This influences the compound's overall reactivity and biological activity, highlighting the importance of structure-activity relationships in medicinal chemistry.
  • Potential Applications: Beyond its medicinal properties, 2-[(2-chlorophenyl)methyl]guanidine serves as a valuable intermediate in the synthesis of other complex molecules. Its versatility makes it significant for materials science and organic synthesis.

In conclusion, 2-[(2-chlorophenyl)methyl]guanidine is more than just a simple compound; it stands at the intersection of chemistry and biology, offering numerous avenues for research and application. As scientists continue to explore its properties, who knows what new discoveries await in the future?

Synonyms
1-(2-chlorobenzyl)guanidine
4406-27-3
N-(2-CHLORO-BENZYL)-GUANIDINE
2-[(2-chlorophenyl)methyl]guanidine
MFCD05022507
N-(2-Chlorobenzyl)guanidine
o-chloro-benzylguanidine
CHEMBL509799
SCHEMBL4023664
STK164644
AKOS003602420
SY340530
N-[(2-CHLOROPHENYL)METHYL]GUANIDINE