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Cyclopropylphenylmethyloxymethylimidazoline

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Identification
Molecular formula
C13H16N2O
CAS number
128604-23-4
IUPAC name
2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole
State
State

At room temperature, it is in a solid state in the form of crystalline powder.

Melting point (Celsius)
92.00
Melting point (Kelvin)
365.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
216.29g/mol
Molar mass
216.2900g/mol
Density
1.1895g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole (C13H16N2O)

The solubility of 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole is an intriguing property that can significantly influence its applications and behavior in different environments. The compound exhibits solubility in various solvents, primarily due to its functional groups and molecular structure.

Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups in the molecule can enhance solubility in polar solvents, while non-polar characteristics can promote solubility in organic solvents.
  • Hydrogen Bonding: This compound may engage in hydrogen bonding with solvents, which can increase solubility in water or alcohols.
  • Molecular Size: Its relatively moderate molecular size also plays a role—larger molecules often have decreased solubility.

In general, it is noted that the solubility of imidazole derivatives can vary greatly, so experimental data should be consulted to acquire specific solubility metrics. “Like dissolves like” is a guiding principle in solubility, meaning that understanding the nature of both solute and solvent is essential for predicting solubility outcomes.

For practical applications, understanding the solubility of this compound ensures proper formulation in pharmaceuticals, where solubility can critically impact bioavailability and efficacy. Prospective users are encouraged to assess solubility in relevant solvents prior to application to ensure optimal performance.

Interesting facts

Interesting Facts about 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole

The compound 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole belongs to a fascinating class of organic molecules known as imidazoles, which are characterized by a five-membered ring containing two nitrogen atoms. This compound showcases unique structural characteristics that contribute to its potential biological and pharmacological activities.

Key Features

  • Cyclopropyl Group: The presence of a cyclopropyl moiety in the structure imparts rigidity and can enhance the compound's potency and selectivity in biological applications.
  • Phenoxy Linkage: The phenoxy group is known for its ability to interact with biological receptors, making this compound a subject of interest for researchers looking to develop new therapeutic agents.
  • Dihydro Imidazole: The dihydro group adds further complexity to the molecular structure, enabling a variety of chemical reactivity that can be exploited in synthesis and medicinal chemistry.

One of the most compelling aspects of 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole is its potential role in drug development. Compounds with imidazole rings are commonly found in many pharmacologically active substances, including antifungal agents and antihistamines. Researchers are continually exploring how variations in structure can lead to more effective drugs with fewer side effects.

As a student or a scientist studying this compound, you might reflect on the insightful quote:

"Chemistry is the science of matter, but it is also a science of change." - This quote highlights the transformative potential of studying compounds like this one.

In summary, 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole exemplifies the intricate relationship between molecular structure and biological activity, making it a compelling subject for further exploration in the realm of medicinal chemistry.

Synonyms
cirazoline
59939-16-1
Cirazoline [INN]
Cirazolina
Cirazolinum
2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole
Cirazolinum [INN-Latin]
Cirazolina [INN-Spanish]
LD-3098
UNII-QK318GVY3Y
QK318GVY3Y
DTXSID4045131
2-((o-Cyclopropylphenoxy)methyl)-2-imidazoline
CHEMBL13852
2-(2'-cyclopropylphenoxymethyl)imidazoline hydrochloride
DTXCID2025131
NCGC00015196-04
1H-Imidazole, 2-((2-cyclopropylphenoxy)methyl)-4,5-dihydro-
Cirazolinum (INN-Latin)
Cirazolina (INN-Spanish)
CAS-59939-16-1
2-((2-cyclopropylphenoxy)methyl)-4,5-dihydro-1H-imidazole
1H-Imidazole, 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-
Tocris-0888
Lopac-C-223
1H-Imidazole, 2-((2-cyclopropylphenoxy)methyl)-4,5-dihydro-, monohydrochloride
Lopac0_000354
BSPBio_001586
GTPL515
KBioGR_000306
KBioSS_000306
SCHEMBL126496
CHEBI:92950
KBio2_000306
KBio2_002874
KBio2_005442
KBio3_000611
KBio3_000612
Bio1_000412
Bio1_000901
Bio1_001390
Bio2_000306
Bio2_000786
HMS1361P08
HMS1791P08
HMS1989P08
HMS2089E21
HMS3402P08
Tox21_110095
BDBM50027060
Tox21_110095_1
CCG-204449
DB09202
SDCCGSBI-0050342.P002
IDI1_034056
NCGC00015196-01
NCGC00015196-02
NCGC00015196-03
NCGC00015196-05
NCGC00015196-06
NCGC00015196-07
NCGC00015196-08
NCGC00015196-09
NCGC00015196-13
NCGC00024847-01
NCGC00024847-02
NCGC00024847-03
NCGC00024847-04
NCGC00024847-05
DB-053499
HY-113985
CS-0064818
NS00068068
L000800
Q5121338
BRD-K54142781-001-02-1
BRD-K54142781-003-02-7
BRD-K54142781-003-08-4
BRD-K54142781-003-11-8
2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole
2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole (cirazoline)