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Tibolone

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Identification
Molecular formula
C21H28O2
CAS number
5630-53-5
IUPAC name
2-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
State
State

At room temperature, Tibolone is in a solid state, specifically as a crystalline powder. It is typically stable when stored under appropriate conditions.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
325.30
Boiling point (Kelvin)
598.45
General information
Molecular weight
328.49g/mol
Molar mass
328.4930g/mol
Density
1.1200g/cm3
Appearence

Tibolone typically appears as a white or almost white, crystalline powder. It may not have any significant odor and is usually stored in a dry environment to maintain its stability.

Comment on solubility

Solubility of 2-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

The solubility of the compound C21H28O2, also known as 2-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one, is influenced by various factors, including its molecular structure and the presence of specific functional groups. Here are some key points to consider:

  • Polarity: Due to the presence of the diethylamino and ethoxy functional groups, the compound exhibits significant polar characteristics, which can enhance its solubility in polar solvents.
  • Solvent Compatibility: This compound is more likely to dissolve in solvents such as ethanol or DMSO, as these solvents can effectively disrupt intermolecular forces.
  • Temperature Effects: Generally, increasing temperature can increase the solubility of solids. Thus, a rise in temperature may aid in solubilizing this compound.
  • Hydrophobic Regions: The hydrophobic segments of the compound may hinder its solubility in water, resulting in low aqueous solubility, making non-polar solvents a better choice for dissolution.

Ultimately, the solubility of this compound can be summarized as moderate in polar organic solvents but limited in water due to its complex structure. As stated often, “Like dissolves like,” thus indicating the importance of selecting the right solvent for optimal dissolution.

Interesting facts

Interesting Facts about 2-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

This compound is a fascinating example of a synthetic organic molecule that combines multiple functional groups, making it an intriguing subject for study in medicinal chemistry and pharmacology.

Key Characteristics

  • Diverse Structure: The presence of a diethylamino group indicates potential biological activity, which is often associated with neurotransmitter interactions.
  • Steroidal Framework: This compound features a complex cyclopentaphenanthrene core, which is characteristic of many steroids and has implications in biochemistry.
  • Medicinal Potential: Compounds with similar structures have been investigated or used in treatments related to hormonal therapies and other pharmacological applications.

As a chemical scientist, one might be particularly intrigued by the synthetic pathway leading to this molecule. The synthesis could involve:

  1. Functionalization: Steps that add the diethylamino group and the ethoxy chain, potentially affecting solubility and activity.
  2. Reduction Reactions: To achieve the specific hydrogenation seen in dodecahydro structures, which can influence pharmacodynamics.

Analyzing 2-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one can provide insights into:

  • The interplay between structure and activity in medicinal chemistry.
  • Potential for designing new derivatives with enhanced efficacy or reduced side effects.
  • Understanding metabolic pathways and pharmacokinetics for therapeutic use.

In conclusion, this compound exemplifies how synthetic chemistry not only contributes to the understanding of molecular structures but also advances the field of drug discovery and development.