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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
2-[2-(diethylamino)ethyl]-3-methyl-2-(1-naphthyl)butanoic acid
State
State

At room temperature, Naproxen is typically found in a solid state. Its crystalline nature makes it suitable for formulation into tablets or capsules for medicinal purposes.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
548.00
Boiling point (Kelvin)
821.15
General information
Molecular weight
230.30g/mol
Molar mass
230.3020g/mol
Density
1.0507g/cm3
Appearence

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) with a crystalline appearance. It is usually encountered as a white to off-white crystalline substance. The compound is often available in tablet form for pharmaceutical use, where it is mixed with various excipients.

Comment on solubility

Solubility of 2-[2-(diethylamino)ethyl]-3-methyl-2-(1-naphthyl)butanoic acid

The solubility of 2-[2-(diethylamino)ethyl]-3-methyl-2-(1-naphthyl)butanoic acid is a fascinating aspect to explore due to its unique structural characteristics. This compound, often referred to in discussions about its pharmaceutical applications, demonstrates varying solubility depending on the solvent used. Here are a few key points to consider:

  • Solvent Polarity: Non-polar solvents may struggle to dissolve this compound effectively due to the presence of both polar and non-polar regions in its structure.
  • Aqueous Solubility: In highly polar solvents like water, the solubility can be significantly enhanced through ionization of the carboxylic acid group, making it more soluble at higher pH levels.
  • Temperature Effects: Increasing temperature often improves solubility, especially when dissolving solid forms of the compound.
  • pH Influence: The solubility of this acid can be significantly affected by the pH of the solution, with a marked increase in solubility in alkaline conditions.

In summary, the solubility of 2-[2-(diethylamino)ethyl]-3-methyl-2-(1-naphthyl)butanoic acid is influenced by several factors, including solvent type, pH, and temperature. Understanding these factors can be crucial for applications in pharmacology and biochemistry where solubility plays a vital role in bioavailability and drug formulation.

Interesting facts

Interesting Facts about 2-[2-(diethylamino)ethyl]-3-methyl-2-(1-naphthyl)butanoic acid

2-[2-(diethylamino)ethyl]-3-methyl-2-(1-naphthyl)butanoic acid, commonly known as a compound in the field of pharmacology, exhibits fascinating properties and applications. Here are some noteworthy points:

  • Pharmaceutical Significance: This compound serves as a vital starting material or metabolic precursor in the synthesis of various pharmacologically active compounds, particularly in the development of analgesics and anti-inflammatory medications.
  • Structure Diversity: The unique structural characteristics of this compound, including the presence of a naphthyl ring, contribute to its biological activity. Such structural diversity is often linked to the binding affinity to specific biological targets.
  • Diethylamino Group: The diethylamino moiety not only contributes to the compound's basicity but also influences its lipophilicity, potentially enhancing absorption and distribution in biological systems.
  • Biological Research: Ongoing studies continue to explore the therapeutic potentials of this compound, particularly its interaction with certain receptors that may mediate pain and inflammation—a focus area in contemporary pharmaceutical research.
  • Mechanistic Insights: Research indicates that compounds with similar architectures can modulate neurotransmitter levels, paving the way for advancements in treating mood disorders and chronic pain syndromes.

In summary, 2-[2-(diethylamino)ethyl]-3-methyl-2-(1-naphthyl)butanoic acid is more than just a chemical compound; it embodies the intersection of chemistry and medicine, showcasing how intricate molecular designs can lead to innovative therapeutic strategies. As researchers continue to uncover its potential, the future looks promising for this intriguing compound.