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Flecainide

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Identification
Molecular formula
C14H20FN1O1
CAS number
54143-55-4
IUPAC name
2-[2-(dimethylamino)ethyl]-2-(4-fluorophenyl)-3-methyl-butanamide
State
State

At room temperature, Flecainide is in a solid state, typically in the form of crystalline powder.

Melting point (Celsius)
141.50
Melting point (Kelvin)
414.65
Boiling point (Celsius)
368.30
Boiling point (Kelvin)
641.45
General information
Molecular weight
265.37g/mol
Molar mass
265.3670g/mol
Density
1.2670g/cm3
Appearence

Flecainide is typically found as a white or almost white crystalline powder. It is odorless and soluble in many organic solvents.

Comment on solubility

Solubility of 2-[2-(dimethylamino)ethyl]-2-(4-fluorophenyl)-3-methyl-butanamide

The solubility of 2-[2-(dimethylamino)ethyl]-2-(4-fluorophenyl)-3-methyl-butanamide can be quite intriguing due to its unique chemical structure. Solubility is affected by various factors such as temperature, pH, and the presence of other solutes. Here are some key points to consider:

  • Polar vs. Nonpolar: This compound features both polar (dimethylamino group) and nonpolar (4-fluorophenyl and alkyl groups) segments, which creates a potential for varying solubility in different solvents.
  • Water Solubility: Due to the presence of the dimethylamino group, which can engage in hydrogen bonding, one might expect moderate solubility in water. However, the nonpolar characteristics could limit this solubility.
  • Organic Solvents: The amphiphilic nature of the compound may enhance its solubility in organic solvents such as ethanol or acetone.
  • Temperature Dependency: Generally, increased temperature can improve the solubility of organic compounds. Therefore, experimenting with temperature adjustments may provide insights into optimal dissolving conditions.

In summary, while one might anticipate some solubility in polar solvents due to the presence of polar functional groups, the compound's overall solubility profile is likely complex and dependent on multiple factors. As a reminder, “Solubility can be a delicate balance of interactions!” Exploration and testing in varied conditions will yield the best understanding of this compound's solubility characteristics.

Interesting facts

Interesting Facts About 2-[2-(dimethylamino)ethyl]-2-(4-fluorophenyl)-3-methyl-butanamide

This compound, often referred to as a member of the amide family, showcases a fascinating array of characteristics that attract attention in both pharmaceutical and chemical research. Here are some key highlights:

  • Biological Activity: This compound has garnered interest due to its potential pharmacological properties. It interacts with various biological targets, which can influence its dynamics in living systems.
  • Role of the Dimethylamino Group: The presence of the dimethylamino functional group is significant. It can enhance solubility and alter the compound's overall polarity, potentially increasing its bioavailability.
  • Fluorine Substitution: The inclusion of a fluorine atom in the structure contributes to the compound’s lipophilicity, which can enhance binding affinity to certain receptors, thus potentially increasing its pharmacological effectiveness.
  • Synthesis and Modifications: The synthetic routes to produce this compound can involve various methods such as amide coupling and alkylation reactions, allowing chemists to explore different modifications that may refine its properties further.
  • Structure-Activity Relationship (SAR): Investigations into the SAR of this compound can yield insights into how small structural changes impact the biological activity, paving the way for lead optimization in drug discovery.

In conclusion, 2-[2-(dimethylamino)ethyl]-2-(4-fluorophenyl)-3-methyl-butanamide is more than just a series of chemical components; its rich structure opens numerous avenues for exploration in medicinal chemistry and pharmacology, making it a compound of great interest to researchers.

Synonyms
BRN 2129577
4-(Dimethylamino)-2-(p-fluorophenyl)-2-isopropylbutyramide
14780-22-4
BUTYRAMIDE, 4-(DIMETHYLAMINO)-2-(p-FLUOROPHENYL)-2-ISOPROPYL-
DTXSID60933224
2-[2-(Dimethylamino)ethyl]-2-(4-fluorophenyl)-3-methylbutanimidic acid