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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
2-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-methyl-butanenitrile
State
State

At room temperature, loperamide is generally a solid.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
379.40
Boiling point (Kelvin)
652.55
General information
Molecular weight
477.03g/mol
Molar mass
477.0330g/mol
Density
1.0580g/cm3
Appearence

Loperamide typically appears as a white to off-white powder. It is odorless and possesses a slightly bitter taste.

Comment on solubility

Solubility of 2-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-methyl-butanenitrile

The solubility of 2-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-methyl-butanenitrile is influenced by several factors due to its complex structure. The following points highlight aspects of its solubility:

  • Polar vs. Non-polar: Although the compound contains polar functional groups, such as the dimethylamino group and the nitrile group, it also has a large hydrophobic aromatic ring. This dual nature can lead to varying solubility in different solvents.
  • Solvent Compatibility: It is expected to be soluble in polar organic solvents like methanol or ethanol. However, its solubility in water may be limited due to the bulkiness of the aromatic group, which can hinder interactions with water molecules.
  • Temperature Effects: Solubility may also change with temperature. As with many organic compounds, higher temperatures can often increase solubility in organic solvents.

In summary, the solubility of 2-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-methyl-butanenitrile can be described as moderate in polar organic solvents while being less soluble in water due to its structural characteristics. Understanding these properties is crucial for applications in various chemical processes.

Interesting facts

Interesting Facts about 2-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-methyl-butanenitrile

This compound, commonly referred to in scientific circles for its unique structure, holds several intriguing properties and applications that make it a subject of interest for researchers and students alike. Here are some notable aspects:

  • Unique Structure: The structure of this compound includes a dimethylamino group, which is known for its basicity and ability to participate in various chemical reactions.
  • Pharmacological Potential: Compounds with similar structural motifs have been investigated for their potential roles in medicinal chemistry, particularly as antidepressants or analgesics.
  • Biological Activity: Due to its modification of the 4-methoxyphenyl moiety, this compound may exhibit interesting interactions with biological systems, which can be studied through in vitro and in vivo assays.
  • Research Applications: Scientists exploring drug design are particularly interested in the structure-activity relationships of compounds like this, as they could pave the way for the discovery of new therapeutic agents.
  • Synthesis Challenges: The preparation of this compound may involve intricate synthetic pathways, requiring careful manipulation of reagents under controlled conditions to achieve purity and yield.

As one dives deeper into the study of 2-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-methyl-butanenitrile, it becomes clear that this compound serves as a reminder of the complexity and beauty of organic chemistry. As one researcher aptly stated, "Every compound is a story waiting to be told, and this one is no exception."

Synonyms
BRN 2131923
4-(Dimethylamino)-2-isopropyl-2-(p-methoxyphenyl)butyronitrile
14795-41-6
BUTYRONITRILE, 4-(DIMETHYLAMINO)-2-ISOPROPYL-2-(p-METHOXYPHENYL)-
DTXSID10933254
2-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-methylbutanenitrile