Skip to main content

Lidocaine

ADVERTISEMENT
Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
2-[2-(dimethylamino)ethyl]-2-isopropyl-3-methyl-butanamide
State
State

At room temperature, lidocaine is typically in solid form as a crystalline powder. It is stable under normal temperatures and pressures.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.95
General information
Molecular weight
234.34g/mol
Molar mass
234.3430g/mol
Density
1.0260g/cm3
Appearence

Lidocaine appears as a white, crystalline, odorless powder which is soluble in alcohol, acetone, and chloroform. It is practically insoluble in water.

Comment on solubility

Solubility of 2-[2-(dimethylamino)ethyl]-2-isopropyl-3-methyl-butanamide

The solubility of 2-[2-(dimethylamino)ethyl]-2-isopropyl-3-methyl-butanamide is influenced by its unique structural features. This compound exhibits notable characteristics due to the presence of functional groups that interact with solvents. Here are some important points regarding its solubility:

  • Polar Nature: The dimethylamino group contributes to the compound's polar characteristics, which may enhance solubility in polar solvents like water.
  • Hydrophobic Portions: The isopropyl and methyl groups provide hydrophobic characteristics, possibly reducing solubility in highly polar environments.
  • Solvent Specificity: Depending on the solvent used, the solubility can vary significantly. It is likely to be more soluble in organic solvents than in water.
  • Concentration Effects: Like many amides, solubility can be concentration-dependent, requiring careful consideration during formulation.
  • Temperature Dependence: Increasing temperature generally enhances solubility for many organic compounds; thus, it can be expected that higher temperatures may improve the solubility of this amide.

In summary, the solubility profile of 2-[2-(dimethylamino)ethyl]-2-isopropyl-3-methyl-butanamide is shaped by its dual hydrophilic and hydrophobic characteristics, making it a compound that may exhibit varying solubility based on the solvent and environmental conditions. Understanding these solubility aspects is essential for its effective application in chemical formulations.

Interesting facts

Interesting Facts about 2-[2-(dimethylamino)ethyl]-2-isopropyl-3-methyl-butanamide

2-[2-(dimethylamino)ethyl]-2-isopropyl-3-methyl-butanamide, often referenced in pharmaceutical contexts, is notable for its complex structure and biological activity. Here are some fascinating aspects of this compound:

  • Pharmacological Significance: This compound is a derivative that plays a vital role in drug development, particularly in the sector of anesthetics and analgesics. Its unique molecular configuration helps modulate pain receptors in the human nervous system.
  • Dimethylamino Group: The presence of the dimethylamino group is crucial. This element enhances the compound's ability to interact with biological systems, demonstrating the importance of functional groups in medicinal chemistry.
  • Stereochemistry: The compound exhibits interesting stereochemical properties due to the presence of multiple chiral centers. This can result in varying biological activity among its isomers, making stereochemical analysis essential in pharmacology.
  • Applications in Research: Frequently utilized in laboratory settings, researchers employ this compound in various studies to understand receptor binding and drug interactions, offering insights into the design of next-generation pharmaceuticals.
  • Structure-Activity Relationship (SAR): The compound's distinct structural features allow scientists to explore their relationship with biological activity. Modifying specific components can yield valuable data for the development of new therapeutic agents.

As chemist Robert H. Grubbs insightfully stated, "The key to drug design lies in understanding how molecular structure interacts with biological systems." The study of 2-[2-(dimethylamino)ethyl]-2-isopropyl-3-methyl-butanamide exemplifies this principle, serving as a vital tool for grasping complex pharmacological interactions.

In conclusion, the rich structural features and biological implications of this compound make it an exciting area of study in organic and medicinal chemistry, helping pave the way for innovations in drug discovery.

Synonyms
3582-38-5
BRN 2358717
BUTYRAMIDE, 2-(2-DIMETHYLAMINOETHYL)-2-ISOPROPYL-3-METHYL-
Butyramide, 2,2,-diisopropyl-4-dimethylamino-
alpha,alpha-Diisopropyl-alpha-(2-dimethylaminoethyl)acetamide
DTXSID30189357
DTXCID60111848
4-(Dimethylamino)-2,2-diisopropylbutyramide