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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
2-[2-(dimethylamino)ethyl]-3-methyl-2-phenyl-butanamide
State
State

At room temperature, Loperamide is in a solid state. It is widely used in medication for its anti-diarrheal properties.

Melting point (Celsius)
224.00
Melting point (Kelvin)
497.15
Boiling point (Celsius)
523.85
Boiling point (Kelvin)
797.00
General information
Molecular weight
477.04g/mol
Molar mass
477.0810g/mol
Density
0.9798g/cm3
Appearence

Loperamide is a white or slightly yellowish powder. It is typically found in solid form and may sometimes be seen in the form of tablets or capsules as it is often used in pharmaceutical applications.

Comment on solubility

Solubility of 2-[2-(dimethylamino)ethyl]-3-methyl-2-phenyl-butanamide

The solubility of 2-[2-(dimethylamino)ethyl]-3-methyl-2-phenyl-butanamide is influenced by its unique molecular structure. This compound, like many organic amides, exhibits varying solubility characteristics depending on factors such as temperature and the solvent used. Here are some key points to consider:

  • Polarity: The presence of the amide functional group contributes to moderate polarity, allowing for some interactions with polar solvents.
  • Chain Length: The ethyl and methyl substituents enhance the molecular size, which can impact solubility in water.
  • Hydrogen Bonding: The capability to form hydrogen bonds increases solubility in solvents like water compared to less polar solvents.
  • Practical Aspects: Solubility may vary when mixed with alcohols, ethers, or other organic solvents, making it crucial to test under specific conditions for practical applications.

In summary, while 2-[2-(dimethylamino)ethyl]-3-methyl-2-phenyl-butanamide may exhibit decent solubility in polar solvents due to its functional groups, understanding its specific interactions is essential for optimal use in scientific applications. Consider conducting solubility testing under varying conditions to fully grasp its behavior.

Interesting facts

Interesting Facts about 2-[2-(Dimethylamino)ethyl]-3-methyl-2-phenyl-butanamide

This compound, often referred to as a member of the amide family, has piqued the interest of many in the fields of medicinal chemistry and drug development. Here are some intriguing aspects:

  • Pharmacological Potential: Compounds containing a dimethylamino group often exhibit significant biological activities. This compound is notable for its potential as a therapeutic agent, particularly in the realm of pain management and anti-inflammatory responses.
  • Synthetic Routes: The synthesis of 2-[2-(dimethylamino)ethyl]-3-methyl-2-phenyl-butanamide involves various organic reactions, including amide formation. This presents an important opportunity for chemists to explore new synthetic methodologies.
  • Structural Features: The presence of the phenyl group adds a level of aromatic stability, which can influence the compound's interactions with biological targets, possibly enhancing its efficacy.
  • Solubilizing Features: The dimethylamino group is known for imparting hydrophilicity, making the compound potentially more soluble in aqueous environments, which is crucial for drug formulation.
  • Research Opportunities: Due to its complex structure, there are many avenues for investigation. Scientists are keen to explore its pharmacodynamics and pharmacokinetics, which are essential for understanding how the compound behaves in biological systems.

As one delves deeper into the study of 2-[2-(dimethylamino)ethyl]-3-methyl-2-phenyl-butanamide, it opens up discussions on structure-activity relationships, a critical concept in medicinal chemistry that explores how different structural components of a compound affect its biological activity.

In summary, this compound is a promising candidate for further research, with its unique features paving the way for advancements in medicinal applications.

Synonyms
BRN 2809206
2977-18-6
BUTYRAMIDE, 4-(DIMETHYLAMINO)-2-ISOPROPYL-2-PHENYL-
alpha-Isopropyl-alpha-(2-dimethylaminoethyl)phenylacetamide
Butyramide, 2-(2-dimethylaminoethyl)-3-methyl-2-phenyl-
DTXSID00952196
2-[2-(Dimethylamino)ethyl]-3-methyl-2-phenylbutanimidic acid