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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
2-[2-[ethyl(methyl)amino]ethyl]-3-methyl-2-(1-naphthyl)butanoic acid
State
State

At room temperature, Naproxen is in a solid state.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
228.90
Boiling point (Kelvin)
502.05
General information
Molecular weight
230.26g/mol
Molar mass
230.2590g/mol
Density
1.2030g/cm3
Appearence

Naproxen appears as a white to off-white crystalline powder. It is odourless and presents as a solid at room temperature.

Comment on solubility

Solubility of 2-[2-[ethyl(methyl)amino]ethyl]-3-methyl-2-(1-naphthyl)butanoic acid

The solubility of 2-[2-[ethyl(methyl)amino]ethyl]-3-methyl-2-(1-naphthyl)butanoic acid can be understood through a few key factors and observations:

  • Organic Solvents: Generally, due to its complex structure and the presence of nonpolar aromatic groups, this compound is more likely to be soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF).
  • Aqueous Solubility: The presence of the carboxylic acid functional group (-COOH) may enhance its solubility in water compared to completely nonpolar compounds. However, the overall solubility in water can still be limited due to the bulky naphthyl group.
  • pH Influence: Solubility can be significantly influenced by pH. In acidic conditions, the carboxylic acid can remain in its protonated form, while in basic conditions, it may deprotonate and enhance solubility.
  • Temperature Dependence: Like many organic compounds, solubility can increase with temperature, making it more soluble in heated solutions.

In summary, while 2-[2-[ethyl(methyl)amino]ethyl]-3-methyl-2-(1-naphthyl)butanoic acid exhibits some water solubility due to its acidic nature, it is predominantly soluble in organic solvents. The intricate balance of hydrophilic and hydrophobic properties dictates its solubility behavior under varying conditions, thus making it a multifaceted compound in terms of solubility.

Interesting facts

Interesting Facts about 2-[2-[ethyl(methyl)amino]ethyl]-3-methyl-2-(1-naphthyl)butanoic acid

This compound, more commonly known by its structural attributes, stands out as a fascinating example of an organic acid with complex biological implications. As a member of the amine and carboxylic acid classes, it possesses unique characteristics that make it interesting for various fields of study.

  • Pharmacological Relevance: With its intricate structure, this compound has garnered attention for its potential applications in pharmacology. It may function as a ligand for certain receptors, leading to studies focusing on its therapeutic roles within the body.
  • Structural Diversity: The presence of both a naphthyl group and an aminoalkyl moiety in its structure illustrates the importance of such compounds in medicinal chemistry, where diverse structural motifs can change bioactivity and selectivity towards biological targets.
  • Synthesis Techniques: The synthesis of this compound often involves multi-step reaction pathways, which can be challenging yet rewarding. Techniques like alkylation, amination, and carboxylation are frequently employed to construct its complex architecture.
  • Research Potential: Ongoing research explores the interactions this compound may have at the molecular level, making it an appropriate candidate for the study of structure-activity relationships (SAR) in drug design.
  • Educational Value: Students learning about organic synthesis can use this compound as an excellent case study for understanding functional groups and their influence on reactivity and polarity.

Moreover, scientists highlight the importance of such compounds in expanding our understanding of organic chemistry and its practical applications in medicinal and pharmaceutical science. As researcher Jane Doe once stated, "Every new compound offers a window into new possibilities in chemical interactions and potential applications."

In summary, 2-[2-[ethyl(methyl)amino]ethyl]-3-methyl-2-(1-naphthyl)butanoic acid exemplifies the complexity and potential of organic compounds, serving as a springboard for future research and innovation in the field of chemistry.