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Zidovudine

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Identification
Molecular formula
C10H14N2O2
CAS number
30516-87-1
IUPAC name
2-(2-hydroxy-1-methyl-ethyl)-6-methyl-1H-pyrimidin-4-one
State
State

Zidovudine is typically in a solid state at room temperature, generally stored in the form of a white to off-white crystalline powder. It is quite stable under standard conditions (25°C and 1 atm).

Melting point (Celsius)
117.50
Melting point (Kelvin)
390.65
Boiling point (Celsius)
482.15
Boiling point (Kelvin)
755.30
General information
Molecular weight
267.24g/mol
Molar mass
267.2430g/mol
Density
1.4410g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. It is often in an amorphous form when prepared for pharmaceutical purposes and may not have a defined crystal structure.

Comment on solubility

Solubility Insights for 2-(2-hydroxy-1-methyl-ethyl)-6-methyl-1H-pyrimidin-4-one

The solubility of 2-(2-hydroxy-1-methyl-ethyl)-6-methyl-1H-pyrimidin-4-one is influenced by its molecular structure and functional groups. As a pyrimidinone derivative, this compound exhibits intriguing solubility characteristics.

Key Factors Affecting Solubility:

  • Polarity: The presence of the hydroxyl group (-OH) makes the compound more polar, which enhances its ability to dissolve in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl group can engage in intermolecular hydrogen bonding, further aiding solubility in aqueous environments.
  • Molecular Interactions: The methyl and ethyl groups in the structure contribute to hydrophobic interactions, which may limit solubility in non-polar solvents.

Quote: "Like dissolves like," meaning that compounds with similar polar characteristics tend to dissolve better in each other. Therefore, this compound is expected to have good solubility in polar media.

Overall, 2-(2-hydroxy-1-methyl-ethyl)-6-methyl-1H-pyrimidin-4-one is likely to exhibit moderate solubility in water, while its solubility in organic solvents might be considerably lower. This unique balance of hydrophilic and hydrophobic characteristics makes it a compound of interest in various chemical and biological applications.

Interesting facts

Interesting Facts about 2-(2-hydroxy-1-methyl-ethyl)-6-methyl-1H-pyrimidin-4-one

This compound, often referred to for its intricate structure, belongs to the class of pyrimidines, which are aromatic heterocycles containing nitrogen atoms. Pyrimidines are vital in various biological processes, particularly in the formation of nucleotides that serve as the building blocks of nucleic acids. Here are some notable facts about this unique compound:

  • Biological Significance: Its structure is reminiscent of several important biological molecules, including those involved in DNA and RNA, making it a subject of interest in genetic research.
  • Pharmacological Potential: Compounds in the pyrimidine family have shown promising effects in medicinal chemistry, and this particular compound may exhibit similar properties, such as antiviral or antitumor activity. Researchers are actively studying these potential applications.
  • Chemical Reactivity: The presence of hydroxyl (-OH) and methyl (-CH3) groups enhances its reactivity, allowing for the possibility of synthetic modifications that can yield new derivatives with improved efficacy and specificity.
  • Role in Synthesis: This compound can be utilized as a precursor in organic synthesis, paving the way for the development of more complex molecules that can be used in pharmaceuticals and agrochemicals.
  • Research Interest: Ongoing studies in the field of organic and medicinal chemistry often focus on derivatives of pyrimidine compounds, leading to discoveries that may enhance our understanding of drug mechanisms.

In conclusion, the compound 2-(2-hydroxy-1-methyl-ethyl)-6-methyl-1H-pyrimidin-4-one exemplifies the *importance of heterocyclic compounds in both nature and synthetic chemistry*. Its potential implications in pharmacology and molecular biology make it a fascinating topic for research and study within the chemistry community.