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Ranitidine

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Identification
Molecular formula
C13H22N4O3S
CAS number
66357-59-3
IUPAC name
2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]-methyl-amino]ethyl-dimethyl-(2-phenylethyl)ammonium
State
State

At room temperature, ranitidine is found in a solid state, specifically as a crystalline powder. Its stability and solubility characteristics make it suitable for pharmaceutical use in various formulations.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
325.15
Boiling point (Kelvin)
598.30
General information
Molecular weight
314.40g/mol
Molar mass
314.4040g/mol
Density
1.3300g/cm3
Appearence

Ranitidine is typically found as a white to pale yellow crystalline powder. It is known for being soluble in water and alcohols, allowing it to be easily administered in tablet or liquid form for medical purposes.

Comment on solubility

Solubility of 2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]-methyl-amino]ethyl-dimethyl-(2-phenylethyl)ammonium

The solubility of 2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]-methyl-amino]ethyl-dimethyl-(2-phenylethyl)ammonium is influenced by several factors, primarily its complex structure and the various functional groups present. This compound contains both hydrophilic and hydrophobic segments, which can lead to intriguing solubility behavior.

Factors Affecting Solubility:

  • Hydrophilicity: The presence of hydroxyl groups (-OH) enhances water solubility by enabling hydrogen bonding.
  • Hydrophobicity: The phenyl groups contribute to hydrophobic interactions, which could decrease solubility in polar solvents.
  • Ionization: The ammonium group may ionize in aqueous solution, further affecting solubility based on pH.

In general, this compound is expected to exhibit variable solubility depending on the solvent used:

Solubility in Different Solvents:

  • Aqueous Solutions: Likely moderate solubility due to the competing effects of hydrophobic and hydrophilic portions.
  • Organic Solvents: Increased solubility in non-polar solvents due to hydrophobic interactions.

As a result, the overall solubility pattern of this compound can be summarized as:

  • Moderate in water, influenced by pH and temperature.
  • High in organic solvents, particularly those that favor hydrophobic interactions.

Thus, understanding the solubility of this compound is crucial for its application in various chemical processes, as it can significantly impact its reactivity and bioavailability.

Interesting facts

Interesting Facts about 2-[[2-Hydroxy-2-phenyl-2-(2-thienyl)acetyl]-methyl-amino]ethyl-dimethyl-(2-phenylethyl)ammonium

This compound is particularly intriguing due to its complex structure and potential applications in various fields, particularly in medicinal chemistry. Here are some interesting insights:

  • Multi-functional Group: The presence of both phenyl and thienyl groups in the compound highlights its versatility. These groups are often found in biologically active molecules, which may suggest potential pharmacological properties.
  • amide Formation: The compound contains an amide linkage, which is known for its significance in peptide bonds and protein structures. This structural trait hints at possible biological activity, making it a subject of research in bio-organic chemistry.
  • Chirality: With multiple chiral centers in its structure, this compound may exhibit enantiomeric diversity. The study of optical isomers can lead to discoveries of differential biological activities, which is crucial in drug development.
  • Potential Applications: Given its complex structure, 2-[[2-hydroxy-2-phenyl-2-(2-thienyl)acetyl]-methyl-amino]ethyl-dimethyl-(2-phenylethyl)ammonium might be explored for:
    • Antidepressant properties
    • Anticancer agents
    • Antimicrobial activity
  • Structure-Activity Relationship (SAR): This compound serves as an excellent model for studying SAR, wherein slight modifications in structure can lead to significant changes in activity, highlighting the importance of structure optimization in drug discovery.

As scientists continue to explore the vast chemistry surrounding compounds like this one, the quest for novel therapeutic agents remains both challenging and exciting. By understanding such compounds, researchers hope to pave the way for innovative treatments.