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Indomethacin

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Identification
Molecular formula
C19H16ClNO4
CAS number
53-86-1
IUPAC name
2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide
State
State
Indomethacin is a solid at room temperature. It usually comes in the form of a crystalline powder for ease of use in pharmaceutical formulations.
Melting point (Celsius)
158.00
Melting point (Kelvin)
431.00
Boiling point (Celsius)
265.80
Boiling point (Kelvin)
538.95
General information
Molecular weight
357.79g/mol
Molar mass
357.7890g/mol
Density
1.4386g/cm3
Appearence

Indomethacin typically appears as a white to yellow crystalline powder. It may also appear as off-white crystals and is practically insoluble in water but soluble in alcohol and acetone. The powder is often used in its crystalline form for pharmaceutical and chemical applications.

Comment on solubility

Solubility of 2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide

The solubility of the compound with the formula C19H16ClNO4 can be discussed in terms of its structural features and functional groups. Understanding solubility is crucial as it affects the compound's efficacy, bioavailability, and potential applications. Here are some key points to consider:

  • Amine Groups: Presence of amino functional groups can enhance solubility in polar solvents such as water by forming hydrogen bonds.
  • Hydrophilicity: The hydroxyamino group contributes to hydrophilicity, suggesting that the compound may have some degree of aqueous solubility.
  • Aliphatic and Aromatic Characteristics: The structure features both aliphatic (pentanamide) and aromatic (indole) components, which may lead to differing solubility in organic solvents.
  • Influence of Chlorine: The chlorine atom may alter solubility, potentially decreasing solubility in non-polar solvents.

In summary, while predictions about solubility can be made based on structural features, the actual solubility can only be determined empirically. As the interactions within solvents can be complex, studies may reveal:

  • Higher solubility in polar solvents due to hydrogen bonding capabilities.
  • Variable solubility in non-polar solvents which may be limited due to the presence of polar groups.

Overall, an empirical assessment will provide definitive insights into the solubility behavior of this compound.

Interesting facts

Interesting Facts about 2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide

This intriguing compound is part of a class of molecules that exhibit significant potential in medicinal chemistry. Here are some fascinating insights:

  • Complex Structure: The compound features a complex structure that includes both indole and amino functionalities. This combination plays a critical role in interactions with biological targets, making it an area of interest in drug design.
  • Therapeutic Potential: Given its unique molecular architecture, the compound may have applications in the treatment of various diseases, particularly those related to the central nervous system. Indole derivatives are known for their diverse biological activities, including antidepressant and anti-inflammatory properties.
  • Mechanism of Action: Research into related compounds indicates that they might function by modulating neurotransmitter activity or other metabolic pathways, thus highlighting the importance of understanding this compound's mechanism of action.
  • Amino Acid Interactions: The presence of hydroxyamino and methylamino groups suggests that the compound could interact favorably with biological receptors or enzymes, potentially enhancing its therapeutic efficacy.
  • Research Interest: Its structure makes it a suitable candidate for academic and industrial research, where scientists are constantly seeking new derivatives to expand the library of bioactive compounds.

In summary, 2-[2-(hydroxyamino)-2-oxo-ethyl]-N-[1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxo-ethyl]-4-methyl-pentanamide stands as a promising molecule that exemplifies the powerful interplay between chemistry and biology. As the field of medicinal chemistry evolves, compounds like this may lead to groundbreaking therapies.

Synonyms
Galardin??
SCHEMBL4293696
INH-3927-PI
HMS3653I13