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Ibuprofen

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Identification
Molecular formula
C13H18O2
CAS number
15687-27-1
IUPAC name
2-(2-hydroxynorbornan-2-yl)-2-phenyl-acetic acid
State
State

Ibuprofen is a solid at room temperature.

Melting point (Celsius)
75.00
Melting point (Kelvin)
348.15
Boiling point (Celsius)
157.00
Boiling point (Kelvin)
430.15
General information
Molecular weight
206.28g/mol
Molar mass
206.2840g/mol
Density
1.1750g/cm3
Appearence

Ibuprofen is a white to off-white crystalline powder. It is practically insoluble in water but is soluble in many organic solvents such as ethanol and methanol. The crystals are typically needle-like or plate-like in appearance.

Comment on solubility

Solubility of 2-(2-hydroxynorbornan-2-yl)-2-phenyl-acetic acid

The solubility of 2-(2-hydroxynorbornan-2-yl)-2-phenyl-acetic acid tends to exhibit interesting characteristics due to its unique molecular structure. This compound is likely to show varying solubility in different solvents, influenced by its functional groups and overall hydrophobic/hydrophilic balance.

Factors Affecting Solubility:

  • Polarity: The presence of the hydroxyl group contributes to the molecule's ability to engage in hydrogen bonding, enhancing its solubility in polar solvents.
  • Hydrophobic Interactions: The substantial phenyl and norbornane ring structures may limit solubility in highly polar solvents.
  • pH Dependence: As a carboxylic acid, its solubility could change dramatically with pH variations, becoming more soluble in alkaline conditions due to deprotonation.

In general, this compound may be expected to be more soluble in organic solvents such as ethanol or methanol, while exhibiting limited solubility in water. As with many organic compounds, it is crucial to assess solubility under specific conditions—temperature, solvent polarity, and pH can all play significant roles.

In conclusion, while solubility in 2-(2-hydroxynorbornan-2-yl)-2-phenyl-acetic acid can be predictable based on chemical principles, experimental determination remains an essential component to fully understand its behavior in various environments.

Interesting facts

Interesting Facts About 2-(2-hydroxynorbornan-2-yl)-2-phenyl-acetic acid

2-(2-hydroxynorbornan-2-yl)-2-phenyl-acetic acid is a fascinating chemical compound that belongs to a class of substances with various applications in the field of organic chemistry. Here are some engaging aspects to consider:

  • Structural Diversity: This compound features a unique bicyclic structure, combining elements of both norbornane and a phenyl group, which is significant in understanding its reactivity and potential applications.
  • Biological Relevance: Compounds similar to this one have found applications in drug design and synthesis. Its structure can potentially influence biological interactions, making it an area of interest in medicinal chemistry.
  • Synthesis Pathways: The synthesis of 2-(2-hydroxynorbornan-2-yl)-2-phenyl-acetic acid is often achieved through complex organic transformations, showcasing the ingenuity of synthetic methodologies in modern chemistry.
  • Reactivity: The presence of the acidic functional group (carboxylic acid) suggests that it may participate in various chemical reactions, such as esterification or amide formation, adding versatility to its use in chemical syntheses.

As a compound, it also serves as a model for studying the effects of substitutions on bicyclic systems and highlights the importance of functional groups in determining reactivity and properties.

In summary, 2-(2-hydroxynorbornan-2-yl)-2-phenyl-acetic acid is not merely a chemical entity; it represents a gateway into the complexities of organic synthesis and biological interactions, providing a rich field for ongoing research and exploration in chemistry.

Synonyms
DTXSID00947002
(2-Hydroxybicyclo(2.2.1)heptan-2-yl)(phenyl)acetic acid
(2-Hydroxybicyclo[2.2.1]heptan-2-yl)(phenyl)acetic acid
RefChem:1049697
DTXCID401375272
24183-94-6
2-NORBORNANACETIC ACID, 2-HYDROXY-alpha-PHENYL-
MLS002703550
2-Hydroxy-.alpha.-phenyl-2-norbornanacetic acid
NSC 100765
2-Hydroxy-alpha-phenyl-2-norbornanacetic acid
CHEMBL1882535
2-(3-hydroxy-3-bicyclo[2.2.1]heptanyl)-2-phenylacetic acid
2-Norbornaneacetic acid, 2-hydroxy-alpha-phenyl-, stereoisomer
NSC100765
2-Norbornaneacetic acid, stereoisomer
NSC-100765
SMR001570267
2-Norbornanacetic acid, 2-hydroxy-.alpha.-phenyl-
2-(2-Hydroxybicyclo[2.2.1]heptan-2-yl)-2-phenylacetic acid
2-(2-Hydroxybicyclo[2.2.1]heptan-2-yl)-2-phenylaceticacid