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2-Iodo-N-phenylacetamide

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Identification
Molecular formula
C9H8INO3
CAS number
56341-41-4
IUPAC name
2-[(2-iodobenzoyl)amino]acetic acid
State
State

At room temperature, 2-[(2-iodobenzoyl)amino]acetic acid is typically a solid. It is often stored and handled in its solid form as a powder or crystals.

Melting point (Celsius)
174.00
Melting point (Kelvin)
447.15
Boiling point (Celsius)
335.00
Boiling point (Kelvin)
608.15
General information
Molecular weight
291.07g/mol
Molar mass
291.0740g/mol
Density
2.1590g/cm3
Appearence

2-[(2-iodobenzoyl)amino]acetic acid appears as a white to off-white crystalline solid. It may also have a slight yellowish tinge, depending on purity and storage conditions.

Comment on solubility

Solubility of 2-[(2-iodobenzoyl)amino]acetic acid

The solubility of 2-[(2-iodobenzoyl)amino]acetic acid in various solvents is an interesting topic for discussion. This compound belongs to the class of amino acids and displays unique solubility properties due to its functional groups. Here are some key points to consider:

  • Polar Solvents: Generally, compounds containing carboxylic acids tend to be soluble in polar solvents like water. The presence of the amino group also contributes to potential hydrogen bonding, which can enhance solubility in water.
  • Organic Solvents: While water solubility is favorable, this compound may exhibit varying solubility in organic solvents such as ethanol or methanol depending on the solvent's polarity and hydrogen bonding capabilities.
  • Influence of Iodine: The presence of iodine in the structure can influence the overall polarity and hence its interaction with different solvents. Iodinated compounds often have lower solubility in polar solvents due to their increased hydrophobicity.
  • Practical Applications: Understanding solubility is crucial for applications in pharmaceuticals and materials science, as it can affect drug formulation and interaction with biological systems.

In summary, while 2-[(2-iodobenzoyl)amino]acetic acid exhibits promising solubility in polar solvents, its overall solubility profile is complex and influenced by the interplay of structural features and external conditions. As “solubility is a key factor in a compound's functionality,” exploring this aspect can lead to significant insights in its practical use.

Interesting facts

Interesting Facts about 2-[(2-Iodobenzoyl)amino]acetic Acid

2-[(2-Iodobenzoyl)amino]acetic acid is a fascinating compound that belongs to the category of amino acids, widely recognized for its various applications in pharmaceuticals and organic chemistry. Here are some intriguing aspects of this compound:

  • Unique Structure: The compound features both an amino group and a carboxylic acid group, which are characteristic of amino acids. Its structure also incorporates an iodobenzoyl group, making it a valuable intermediate in chemical syntheses.
  • Pharmaceutical Relevance: Due to the presence of the iodine atom, this compound may exhibit unique biological properties. Iodine is known for its role in a range of biological processes, including thyroid function, which can lead to interesting pharmaceutical applications.
  • Conjugate Base: When the carboxylic acid group dissociates, it forms the conjugate base of this amino acid. This property is essential in biological systems, where amino acids act as zwitterions, carrying both positive and negative charges.
  • Potential Uses: Its structural characteristics make 2-[(2-iodobenzoyl)amino]acetic acid a promising candidate in drug design, especially in targeted therapies where the iodine substituent may enhance the pharmacokinetic profiles of drug candidates.
  • Research Interest: This compound is a subject of academic research, particularly in the field of medicinal chemistry. Researchers investigate its efficacy and safety in drug development, reflecting the ongoing quest for innovative therapies.

In summary, 2-[(2-Iodobenzoyl)amino]acetic acid is more than just a simple compound; it embodies the complexities and exciting possibilities of chemical research, holding potential for significant advancements in various fields.

Synonyms
2-Iodohippuric acid
147-58-0
O-Iodohippuric acid
2-(2-Iodobenzamido)acetic acid
IODOHIPPURIC ACID
2'-Iodohippuric Acid
Glycine, N-(2-iodobenzoyl)-
2-[(2-iodobenzoyl)amino]acetic acid
Iodohippurate
2-[(2-iodophenyl)formamido]acetic acid
N-(2-Iodobenzoyl)glycine
ortho-iodohippuric acid
o-iodobenzoylglycine
DTXSID8046161
ortho-iodobenzoylglycine
3Y68K91A3M
N-(o-iodobenzoyl)glycine
EINECS 205-693-5
2-(2-Iodobenzamido)aceticacid
DTXCID6026161
CHEBI:140408
IODOHIPPURIC ACID [WHO-DD]
O-IODOHIPPURIC ACID [USP-RS]
NCGC00160456-01
ortho-iodohippurate
Acid, Iodohippuric
O-IODOHIPPURIC ACID (USP-RS)
2-((2-iodophenyl)formamido)acetic acid
CAS-147-58-0
UNII-3Y68K91A3M
I Hippuran
I-Hippuran
orthoiodohippurate
Iodobenzoylglycine
ortho Iodohippurate
Glycine, N-(2-iodobenzoyl)-; Hippuric acid, o-iodo- (6CI,8CI); N-(2-Iodobenzoyl)glycine; 2-Iodohippuric acid; N-(o-Iodobenzoyl)glycine; o-Iodohippuric acid
2-iodohippuric-acid
MFCD00002694
I OIH
I-OIH
IODOHIPPURIC 2-
2-Iodohippuric acid, 98%
CHEMBL1681
NCIOpen2_008020
IODOHIPPURATE [VANDF]
Glycine,N-(2-iodobenzoyl)-
MLS004773944
SCHEMBL589803
AAA14758
STR01314
Tox21_111826
[(2-Iodobenzoyl)amino]acetic acid #
AKOS000120821
Tox21_111826_1
DB15445
HY-W141890
NCGC00160456-02
NCGC00160456-03
SMR002529473
DB-329166
CS-0201684
I0446
NS00024834
EN300-18563
D91155
SBI-0653936.0001
BRD-K56634222-001-03-0
Q25323818
Z85887266
o-Iodohippuric acid, United States Pharmacopeia (USP) Reference Standard
205-693-5
InChI=1/C9H8INO3/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13/h1-4H,5H2,(H,11,14)(H,12,13