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Metformin

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Identification
Molecular formula
C4H11N5
CAS number
657-24-9
IUPAC name
2-[2-(isobutylamino)ethyl]guanidine
State
State
At room temperature, Metformin is in a solid state. It is usually found in crystalline form and is primarily used in tablet form for medical applications.
Melting point (Celsius)
223.00
Melting point (Kelvin)
496.00
Boiling point (Celsius)
261.00
Boiling point (Kelvin)
534.00
General information
Molecular weight
129.16g/mol
Molar mass
129.1640g/mol
Density
1.3000g/cm3
Appearence

Metformin is typically found as a white to off-white crystalline solid. It is odorless and hygroscopic, meaning it can absorb moisture from the air. The solid form is usually presented in a powder-like consistency.

Comment on solubility

Solubility of 2-[2-(isobutylamino)ethyl]guanidine

The solubility of 2-[2-(isobutylamino)ethyl]guanidine can be quite intriguing due to the presence of both hydrophilic and hydrophobic components in its structure. The compound features a guanidine group, which is typically known for its ability to form strong hydrogen bonds, enhancing its solubility in polar solvents such as water. However, the isobutyl group introduces a nonpolar characteristic that may reduce solubility to some extent.

Key points regarding its solubility are as follows:

  • Polar Solvents: The compound is expected to be soluble in water and other polar solvents due to the polar guanidine moiety.
  • Nonpolar Solvents: There may be limited solubility in nonpolar solvents due to the hydrophobic nature of the isobutyl group.
  • Temperature Dependence: Solubility may increase with elevated temperatures, which can enhance molecular interactions.
  • pH Influence: The pH of the solution may also impact solubility, as guanidines can be protonated under acidic conditions, thereby affecting solubility.

In summary, while 2-[2-(isobutylamino)ethyl]guanidine demonstrates promising solubility in polar environments, the balance of hydrophilic and hydrophobic character results in variable solubility profiles in different solvents, making it a subject of interest for various applications.

Interesting facts

Interesting Facts About 2-[2-(isobutylamino)ethyl]guanidine

2-[2-(isobutylamino)ethyl]guanidine, often referred to in the realm of pharmacochemistry, is a compound that has garnered attention for its intriguing biological properties. Here are some fascinating insights:

  • Role in Pharmacology: This compound acts as a potent guanylate cyclase activator, which plays a significant role in cardiovascular therapy. By influencing nitric oxide signaling, it can aid in regulating blood pressure and vascular function.
  • Research Applications: 2-[2-(isobutylamino)ethyl]guanidine is studied for its potential therapeutic effects in conditions such as heart failure and hypertension, making it an essential subject for ongoing research in cardiology.
  • Structural Characteristics: The presence of the isobutylamino group is particularly interesting as it enhances the lipophilicity of the compound, impacting its ability to cross biological membranes and thus influencing its bioavailability.
  • Synthetic Pathways: The synthesis of this compound involves sophisticated organic reactions that emphasize the capabilities of modern synthetic chemistry, showcasing techniques such as amination and guanidination.
  • Mechanism of Action: Its mechanism can provide insights into signal transduction pathways and cellular response, establishing important connections between chemistry and biochemistry.

As researchers continue to delve into the properties and applications of 2-[2-(isobutylamino)ethyl]guanidine, it remains a prime example of how chemical compounds can bridge the gap between basic chemistry and real-world medical applications.

Synonyms
SCHEMBL24177193