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Oxymetazoline

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Identification
Molecular formula
C16H24N2O
CAS number
1491-59-4
IUPAC name
2-[(2-isopropyl-5-methyl-phenoxy)methyl]-4,5-dihydro-1H-imidazole
State
State

Oxymetazoline is typically a liquid at room temperature in its pure form, but it can also be found as a solid in its hydrochloride salt form, which is commonly used in pharmaceutical preparations.

Melting point (Celsius)
61.00
Melting point (Kelvin)
334.20
Boiling point (Celsius)
354.50
Boiling point (Kelvin)
627.70
General information
Molecular weight
260.38g/mol
Molar mass
260.3690g/mol
Density
1.0910g/cm3
Appearence

Oxymetazoline appears as a colorless to light yellow liquid or crystalline substance. It is often used in hydrochloride form, which is a fine white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[(2-isopropyl-5-methyl-phenoxy)methyl]-4,5-dihydro-1H-imidazole

The solubility of 2-[(2-isopropyl-5-methyl-phenoxy)methyl]-4,5-dihydro-1H-imidazole in various solvents can be influenced by several factors, making it an intriguing compound to evaluate. Solubility can generally be assessed considering the following points:

  • Polarity: The presence of different functional groups can lead to diverse interactions with solvents. This compound includes a phenoxy group, which usually enhances solubility in organic solvents.
  • Temperature: As with many compounds, solubility often increases with temperature. Therefore, this imidazole derivative may exhibit improved solubility at elevated temperatures.
  • pH Dependence: The solubility may be affected by the pH of the solution, especially since imidazole derivatives can be protonated under acidic conditions, altering their solubility profile.

It’s often observed that compounds with similar functional groups tend to follow like dissolves like principles, which means:

  • This compound is likely to be more soluble in non-polar or weakly polar organic solvents.
  • Conversely, it may be less soluble in highly polar solvents like water.

In practical terms, for researchers and chemists, understanding the solubility characteristics of this compound can be vital for applications in pharmaceutical formulation and chemical analysis. The diverse interactions highlighted by the solubility study provide insights into potential applications in various fields.

Interesting facts

Interesting Facts about 2-[(2-isopropyl-5-methyl-phenoxy)methyl]-4,5-dihydro-1H-imidazole

This intriguing compound, known for its complex structure and unique chemical properties, is a fascinating subject for chemical research. Here are some intriguing points to consider:

  • Pharmaceutical Significance: This compound may be of interest in medicinal chemistry due to its potentially beneficial biological activities. Compounds in the imidazole family are often studied for their role in drug development, particularly in anti-inflammatory and antimicrobial agents.
  • Structural Diversity: The presence of an isopropyl and a methyl group within its structure significantly impacts the compound's lipophilicity and, consequently, its biological activity. This is an excellent example of how small structural changes can lead to varied properties and functions.
  • Research Applications: Researchers are increasingly interested in evaluating the derivative's potential applications in various fields, including agriculture as a pesticide or herbicide. Understanding the chemical behavior of compounds like this could lead to sustainable solutions in crop protection.
  • Synthetic Routes: The methods to synthesize this compound can provide insight into advanced organic synthesis techniques, making it a great teaching example in the realm of synthetic organic chemistry.
  • Environmental Impact: As is the case with many organic compounds, assessing the environmental impact and degradation pathways of this compound is essential, especially in the context of its potential use in agricultural practices.

In summary, 2-[(2-isopropyl-5-methyl-phenoxy)methyl]-4,5-dihydro-1H-imidazole is not just an ordinary compound; it's a gateway into the rich world of chemical research and applications. Its diverse implications in pharmaceutical and agricultural sciences make it a noteworthy topic for ongoing study and exploration.

Synonyms
Tymazoline
24243-97-8
Pernazene
Tymazolin
Tymazoline [BAN]
Tymazoline (BAN)
2-(Thymyloxymethyl)glyoxalidine
UNII-U993RH5585
TYMAZOLINE [MI]
U993RH5585
TYMAZOLINE [WHO-DD]
2-Imidazoline, 2-((thymyloxy)methyl)-
DTXSID40178939
2-(2-Isopropyl-5-methylphenoxymethyl)-2-imidazoline
1,4,5-Dihydro-2-(2-isopropyl-5-methylphenoxymethyl)imidazol
Pernazene (TN)
2-[5-methyl-2-(propan-2-yl)phenoxymethyl]-4,5-dihydro-1H-imidazole
1H-Imidazole, 4,5-dihydro-2-((5-methyl-2-(1-methylethyl)phenoxy)methyl)-
2-(5-methyl-2-(propan-2-yl)phenoxymethyl)-4,5-dihydro-1H-imidazole
RefChem:192635
DTXCID50101430
QRORCRWSRPKEHR-UHFFFAOYSA-N
2-[(5-methyl-2-propan-2-ylphenoxy)methyl]-4,5-dihydro-1H-imidazole
2-(Thymyloxymethyl)glyoxalidine; Pernazene
SCHEMBL250491
CHEMBL2106467
SCHEMBL29387735
CHEBI:134947
DB08803
DB-050130
NS00068084
D07373
Q9363588