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Yohimbine

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Identification
Molecular formula
C21H26N2O3
CAS number
146-48-5
IUPAC name
2-(2-methoxy-1H-indol-3-yl)ethyl-trimethyl-ammonium
State
State

At room temperature, yohimbine is found in a solid state. It is stable under standard conditions and is typically stored in dry environments to maintain its integrity.

Melting point (Celsius)
231.00
Melting point (Kelvin)
504.15
Boiling point (Celsius)
530.80
Boiling point (Kelvin)
803.95
General information
Molecular weight
354.45g/mol
Molar mass
354.4710g/mol
Density
1.2920g/cm3
Appearence

Yohimbine, also known as 2-(2-methoxy-1H-indol-3-yl)ethyl-trimethyl-ammonium, typically appears as a white, crystalline powder. It can also appear as a colorless solid if it is in its purest form.

Comment on solubility

Solubility of 2-(2-methoxy-1H-indol-3-yl)ethyl-trimethyl-ammonium

The solubility of 2-(2-methoxy-1H-indol-3-yl)ethyl-trimethyl-ammonium in various solvents is quite intriguing due to its unique structural features. Here are some key points regarding its solubility:

  • Polar Solvents: This compound is expected to show good solubility in polar solvents such as water and alcohols due to the presence of the quaternary ammonium group, which can participate in hydrogen bonding.
  • Non-Polar Solvents: Conversely, its solubility in non-polar solvents might be limited because the hydrophobic regions could hinder interaction with non-polar molecules.
  • pH Influence: The solubility may also vary with pH; in acidic conditions, protonation of the nitrogen can enhance solubility.
  • Temperature Dependence: Like many organic compounds, solubility could increase with temperature, facilitating greater dissolution in warm solvents.

To summarize, the solubility characteristics of this compound are largely governed by its quaternary ammonium nature and structural configuration. Understanding these properties is essential for applications in organic chemistry and related fields.

Interesting facts

Fascinating Insights into 2-(2-methoxy-1H-indol-3-yl)ethyl-trimethyl-ammonium

2-(2-methoxy-1H-indol-3-yl)ethyl-trimethyl-ammonium is a unique compound that has garnered interest in various fields of research, particularly in medicinal chemistry and biochemistry. Here are some intriguing facts about this compound:

  • Indole Derivative: The compound contains an indole structure, which is known for its role in many biologically active molecules, including neurotransmitters and other physiologically significant substances.
  • Quaternary Ammonium Salt: The presence of the trimethylammonium group suggests that this compound can engage in ionic interactions, making it particularly interesting for studies on cellular uptake and transport mechanisms.
  • Potential Biological Activities: Compounds similar to this one have been studied for their potential roles in cancer therapy and as neuroprotective agents due to their interactions with biological systems.
  • Structure-Activity Relationship: The methoxy group and the ethyl chain can influence the compound's hydrophilicity and lipophilicity, which in turn affects its pharmacokinetics and mechanism of action.

"The indole structure is one of nature's key building blocks for many compounds that are critical for life."

Moreover, research on this compound may provide insights into drug design and the development of new therapeutic agents. As scientists continue to uncover the myriad effects of related compounds, the potential applications of 2-(2-methoxy-1H-indol-3-yl)ethyl-trimethyl-ammonium could expand significantly in the future.