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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
2-(2-methoxyethylamino)-N-(2,4,6-trimethylphenyl)acetamide
State
State

At room temperature, Lidocaine is a solid. It is usually available as a crystalline powder or compacted in solid forms like tablets, which can be dissolved for use in solutions.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3360g/mol
Density
1.0300g/cm3
Appearence

Lidocaine is typically a white crystalline powder. It is odorless and often appears in a fine particulate form. It is commonly used in the form of a hydrochloride salt, which is water-soluble.

Comment on solubility

Solubility Overview

The compound 2-(2-methoxyethylamino)-N-(2,4,6-trimethylphenyl)acetamide exhibits interesting solubility characteristics that may influence its applications in various fields such as pharmaceuticals and chemical research.

Solubility Characteristics

  • Solvent Dependence: The solubility of this compound is influenced by the choice of solvent. Polar solvents such as water and ethanol are typically more favorable for amide compounds due to their ability to form hydrogen bonds.
  • Temperature Impact: As with many organic compounds, increased temperatures generally enhance solubility. It is crucial to assess solubility at different temperatures for practical applications.
  • Structural Factors: The presence of the methoxyethylamino group suggests enhanced solubility in polar solvents due to its ability to interact favorably through hydrogen bonding.
  • pH Sensitivity: Changes in pH can alter the ionization state of the amine moiety, impacting overall solubility. Hence, testing under various pH conditions can yield valuable insights.

Conclusions

Given these factors, researchers should consider performing empirical solubility tests to gain a clearer understanding of how this compound behaves in different environments. The phrase, "Solubility is key to a compound's utility," is particularly true for 2-(2-methoxyethylamino)-N-(2,4,6-trimethylphenyl)acetamide, emphasizing the importance of adaptive testing in diverse conditions.

Interesting facts

Interesting Facts About 2-(2-methoxyethylamino)-N-(2,4,6-trimethylphenyl)acetamide

This chemical compound has garnered significant attention in the field of medicinal chemistry due to its unique structure and potential applications. Here are some fascinating aspects to consider:

  • Diverse Applications: The compound is being investigated for its role in developing therapeutic agents. Its ability to interact with biological systems opens doors for treating various conditions.
  • Structure-Activity Relationship (SAR): Studies of this compound often focus on how modifications to its structure influence biological activity. This can lead to more effective drug designs.
  • Amide Linkage: The presence of the amide functional group in the structure is vital for its chemical stability and biological interactions. Amides frequently serve as core structures in pharmaceuticals.
  • Hydrophilic and Lipophilic Properties: The combination of a methoxy group and a trimethylphenyl group contributes to a balance between hydrophilicity and lipophilicity, impacting the compound's solubility and permeability in biological systems.
  • Research and Development: This compound is often used as a template in the synthesis of related compounds, providing a framework for optimizing drug candidates.

In summary, 2-(2-methoxyethylamino)-N-(2,4,6-trimethylphenyl)acetamide exemplifies the complexity and innovation found in modern drug design. As research progresses, we may uncover even more beneficial properties and applications for this intriguing compound.

Synonyms
BRN 2981310
22151-66-2
ACETANILIDE, 2-((2-METHOXYETHYL)AMINO)-2',4',6'-TRIMETHYL-
2-(2-Methoxyethylamino)-2',4',6'-trimethylacetanilide
DTXSID10176684
RefChem:315708
DTXCID3099175
AKOS005321919