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2-Methoxyphenylacetic acid

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Identification
Molecular formula
C9H10O3
CAS number
93-02-7
IUPAC name
2-(2-methoxyphenyl)acetic acid
State
State
2-Methoxyphenylacetic acid is a solid at room temperature. It is typically stable and requires no special handling procedures beyond typical safety precautions for handling chemical substances.
Melting point (Celsius)
85.00
Melting point (Kelvin)
358.15
Boiling point (Celsius)
332.20
Boiling point (Kelvin)
605.35
General information
Molecular weight
166.18g/mol
Molar mass
166.1770g/mol
Density
1.1960g/cm3
Appearence

2-Methoxyphenylacetic acid typically appears as a white crystalline solid. It can exhibit a slightly shiny surface depending on its crystalline arrangement and level of purity. The solid form is common and it may be powdery or contain small grains.

Comment on solubility

Solubility of 2-(2-methoxyphenyl)acetic acid

2-(2-methoxyphenyl)acetic acid, also known as 2-Methoxyphenylacetic acid or MPAA, exhibits interesting solubility properties that are crucial for its applications. The solubility of this compound can be influenced by various factors, including temperature, pH, and the presence of other solvents.

General Solubility Behavior

  • In Water: 2-(2-methoxyphenyl)acetic acid has limited solubility in water. This can be attributed to its hydrophobic aromatic ring, which reduces its interactions with water molecules.
  • In Organic Solvents: The compound demonstrates good solubility in a range of organic solvents, such as ethanol, acetone, and chloroform. This makes it easier to use in organic synthesis and reactions.

Influencing Factors

The solubility of 2-(2-methoxyphenyl)acetic acid can be enhanced by:

  • Increasing the temperature: As temperature rises, solubility in both water and organic solvents tends to increase.
  • Changing pH: The ionization of the carboxylic acid group can alter solubility; in basic conditions, it can form a salt, improving its solubility in aqueous solutions.

In summary, while 2-(2-methoxyphenyl)acetic acid's solubility in water is somewhat limited, its good compatibility with organic solvents and the ability to manipulate solubility through temperature and pH adjustments provides valuable versatility in various chemical processes.

Interesting facts

Interesting Facts about 2-(2-Methoxyphenyl)acetic Acid

2-(2-Methoxyphenyl)acetic acid, often referenced in the realm of medicinal chemistry, is a fascinating compound due to its distinct chemical structure and potential applications. Here are some intriguing insights:

  • Pharmaceutical Relevance: This compound serves as a structural analog of the renowned drug Ibuprofen, a widely used nonsteroidal anti-inflammatory drug (NSAID). The similarity allows researchers to explore its potential anti-inflammatory and analgesic properties.
  • Synthetic Pathways: The synthesis of 2-(2-methoxyphenyl)acetic acid invites chemists to utilize various aromatic substitution reactions, showcasing the beauty of organic synthesis and the versatility of aromatic compounds.
  • Biological Activity: Studies suggest that derivatives of this compound may exhibit various biological activities, including antioxidant and antimicrobial properties. This prompts further exploration in drug design and development.
  • Research Potential: As research continues, 2-(2-methoxyphenyl)acetic acid has become a focal point for investigating new therapeutic strategies in areas ranging from pain relief to inflammation control.

In summary, 2-(2-methoxyphenyl)acetic acid is more than just a chemical compound. Its structural characteristics and biological interactions make it a promising candidate for further research in medicinal chemistry. As stated by leading researchers in the field, "The potential of this compound lies not only in its structure but also in the endless possibilities it presents for scientific exploration."

Synonyms
2-Methoxyphenylacetic acid
93-25-4
2-(2-methoxyphenyl)acetic acid
Benzeneacetic acid, 2-methoxy-
Acetic acid, (o-methoxyphenyl)-
(o-Methoxyphenyl)acetic acid
2-methoxybenzeneacetic acid
(2-Methoxyphenyl)acetic acid
MFCD00004321
EINECS 202-231-4
NSC 110708
DWF2D897KB
(2-methoxy-phenyl)-acetic acid
2-methoxyphenylaceticacid
DTXSID0059083
NSC-110708
o-METHOXYPHENYLACETIC ACID
UNII-DWF2D897KB
(oMethoxyphenyl)acetic acid
2-?Methoxyphenylacetic acid
2-methoxy phenylacetic acid
2-methoxy-phenylacetic acid
2-methoxyphenyl acetic acid
2-methoxy-benzeneacetic acid
Benzeneacetic acid, 2methoxy
2-methoxy phenyl acetic acid
Acetic acid, (omethoxyphenyl)
SCHEMBL155982
(2-methoxyphenyl)-acetic acid
(S)-2-methoxyphenylacetic acid
CHEMBL5399335
DTXCID1048833
2-(2-methoxyphenyl)-acetic acid
[2-(methyloxy)phenyl]acetic acid
2-Methoxyphenylacetic acid, 98%
CS-D0984
NSC16257
NSC-16257
NSC110708
STL168986
Acetic acid, (omethoxyphenyl) (8CI)
AKOS000120534
FM25266
AC-23644
SY014484
TS-02230
DB-028139
M0533
NS00039538
EN300-20940
F11410
Q63408954
F2191-0109
Z104485032
2-Methoxy-benzeneacetic acid;(o-Methoxyphenyl)acetic acid
202-231-4