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2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid

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Identification
Molecular formula
C16H12N2O3
CAS number
1137-42-4
IUPAC name
2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid
State
State

At room temperature, this compound is in a solid state, typically forming part of pharmaceutical formulations or as an intermediate in organic synthesis.

Melting point (Celsius)
245.00
Melting point (Kelvin)
518.15
Boiling point (Celsius)
405.00
Boiling point (Kelvin)
678.15
General information
Molecular weight
278.29g/mol
Molar mass
278.2890g/mol
Density
1.4321g/cm3
Appearence

2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid appears as a crystalline solid. It generally has a pale yellow to beige color, although this can vary depending on purity and form. It is important to store it in a well-closed container, away from moisture and heat to maintain its stability.

Comment on solubility

Solubility of 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid

The solubility of 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid is a crucial aspect to consider when evaluating its potential applications and effectiveness in various environments. This compound, characterized by its unique functional groups, exhibits specific solubility properties which can be influenced by several factors:

  • Polarity: The presence of the carboxylic acid group in 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid enhances its polarity, thus impacting its solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with the solvent molecules can significantly improve the solubility of this compound in aqueous solutions.
  • pH Levels: The solubility may vary with changing pH levels due to the ionization of the carboxylic acid group, potentially making it more soluble in basic conditions.
  • Temperature: Typically, increased temperature can enhance solubility; however, this can vary depending on the specific interactions with the solvent.

In summary, while 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid exhibits enhanced solubility in polar solvents primarily due to its acidic functionality, understanding the specific conditions and interactions is essential for practical applications. As it has been noted, "Knowledge of solubility helps in predicting the behavior of compounds in biological systems and industrial processes."

Interesting facts

Interesting Facts about 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid

2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid is a fascinating compound that combines the structure of benzoic acid with a quinazoline moiety, which is notable for its versatility in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Bioactivity: This compound has garnered attention due to its potential biological activities. Compounds incorporating quinazoline structures have been studied for their ability to inhibit various enzymes and have shown promise in anti-cancer and anti-inflammatory applications.
  • Structure-Activity Relationship (SAR): The presence of the 2-methyl and 4-oxo substituents enhances the compound's ability to interact with biological targets. Understanding how these modifications affect biological activity is crucial in drug design.
  • Synthesis: The synthesis of this compound typically involves the condensation of appropriate intermediates, revealing intriguing synthetic pathways. This offers an excellent opportunity for both academic and industrial research to explore greener and more efficient synthesis methods.
  • Applications in Pharmacology: Due to its structural features, 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid may serve as a lead compound for developing new pharmaceuticals. Researchers often explore how slight modifications can lead to new therapeutic agents.

In conclusion, studying 2-(2-methyl-4-oxo-quinazolin-3-yl)benzoic acid not only highlights the complexity of chemical structures but also opens up pathways for innovative drug development. As we continue to unravel the potential of such compounds, the interdisciplinary nature of chemistry becomes even more evident.

Synonyms
4005-06-5
2-(2-methyl-4-oxoquinazolin-3(4h)-yl)benzoic acid
2-(2-methyl-4-oxo-4 h-quinazolin-3-yl)-benzoic acid
2-(2-methyl-4-oxoquinazolin-3-yl)benzoic acid
2-(2-Methyl-4-oxo-4 H -quinazolin-3-yl)-benzoic acid
2-(2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)benzoic acid
2-(2-Methyl-4-oxo-3(4H)-quinazolinyl)benzoic acid
DTXSID50274592
EAA00506
MFCD02197929
AKOS003593717
BS-37790
2-(2-Methyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid