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2-(2-phenylethoxy)guanidine

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Identification
Molecular formula
C9H13N3O
CAS number
21734-95-8
IUPAC name
2-(2-phenylethoxy)guanidine
State
State

At room temperature, 2-(2-phenylethoxy)guanidine is typically a solid. This makes it relatively stable for handling and storage under standard laboratory conditions.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
191.22g/mol
Molar mass
191.2510g/mol
Density
1.1000g/cm3
Appearence

2-(2-phenylethoxy)guanidine typically appears as a white to off-white crystalline solid. It may also be available as a powder form depending on the specific preparation and purity.

Comment on solubility

Solubility of 2-(2-phenylethoxy)guanidine

The solubility of 2-(2-phenylethoxy)guanidine can be influenced by various factors including the solvent used, temperature, and ionic interactions. Understanding its solubility is crucial for practical applications such as drug formulation and chemical synthesis.

Key Points on Solubility:

  • Polarity: The compound contains both polar and non-polar functional groups, which can lead to variable solubility in different solvents.
  • Solvent Type: Typically, organic compounds like 2-(2-phenylethoxy)guanidine are more soluble in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) compared to water.
  • Temperature: Solubility often increases with temperature; hence, heating the solvent could enhance the dissolution process.
  • Ionic Interactions: The presence of guanidine, which possesses a basic nitrogen atom, can lead to interactions with acids or salts, potentially improving solubility in particular ionic environments.

In conclusion, while 2-(2-phenylethoxy)guanidine may not be soluble in water to a significant extent, it displays better solubility in non-polar or moderately polar organic solvents. As quoted, “A compound's solubility is a reflection of its molecular interactions,” indicating that understanding its characteristics is vital for potential applications.

Interesting facts

Interesting Facts about 2-(2-phenylethoxy)guanidine

2-(2-phenylethoxy)guanidine is a fascinating compound that captures the interest of chemists for several reasons:

  • Pharmaceutical Potential: This compound has garnered attention in the pharmaceutical field due to its potential applications as a pharmacologically active agent. Its unique guanidine structure is known for its ability to interact with biological systems, which can lead to the development of new therapeutic agents.
  • Mechanism of Action: The guanidine group often exhibits diverse biological activities, which can include antimicrobial, antiviral, and antiparasitic properties. The incorporation of the phenylethoxy group enhances its lipophilicity, potentially improving its ability to cross biological membranes.
  • Structure-Activity Relationships (SAR): Researchers often explore the SAR of guanidine derivatives to optimize their efficacy. The substitution pattern, like that of the 2-phenylethoxy moiety, can significantly influence the compound's biological profile, making this an area of dynamic exploration in medicinal chemistry.
  • Synthetic Routes: The synthesis of 2-(2-phenylethoxy)guanidine can involve various methods, including multi-step organic reactions. Understanding these synthetic pathways is crucial for chemists who wish to produce this compound in a laboratory setting for further study.
  • Research Opportunities: The exploration of analogs and derivatives of 2-(2-phenylethoxy)guanidine can lead to the discovery of compounds with improved pharmacological properties. This ongoing research keeps this compound relevant in the ever-evolving field of drug discovery.

In summary, 2-(2-phenylethoxy)guanidine is a compound rich in potential and significance, making it an exciting subject for both advanced research and practical applications in the medical field. Its structural characteristics and the relationships between its components are key to unlocking new developments in pharmacology.

Synonyms
N-(2-Phenylethoxy)guanidine
1885-50-3
SCHEMBL10773629
DTXSID301310273