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Propofol

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Identification
Molecular formula
C22H31NO4
CAS number
2078-54-8
IUPAC name
2-[2-phenylethyl-[2-(propylcarbamoyloxy)ethyl]amino]ethyl N-propylcarbamate
State
State

Propofol is commonly in the form of an emulsion that is used for intravenous administration. In its pure form, it is a liquid at room temperature.

Melting point (Celsius)
-7.00
Melting point (Kelvin)
266.15
Boiling point (Celsius)
489.10
Boiling point (Kelvin)
762.30
General information
Molecular weight
383.51g/mol
Molar mass
383.5070g/mol
Density
1.1650g/cm3
Appearence

Propofol is a colorless liquid with a slightly pungent smell. It is typically found in an oil-in-water emulsion as it is not soluble in water. The emulsion appears milky white and is used in medical formulations.

Comment on solubility

Solubility Overview

The compound 2-[2-phenylethyl-[2-(propylcarbamoyloxy)ethyl]amino]ethyl N-propylcarbamate exhibits distinctive solubility characteristics that reflect its complex structure.

Solubility in Solvents

Understanding its solubility is essential for applications and formulation. Here are some key points:

  • Polar Solvents: Due to the presence of carbamate and hydroxyl groups, this compound is likely to show greater solubility in polar solvents such as water, methanol, and ethanol.
  • Non-Polar Solvents: Conversely, solubility in non-polar solvents like hexane or toluene is expected to be minimal. The large phenyl group may contribute to moderate interaction, but the overall structure leans towards polarity.

Factors Influencing Solubility

Several factors affect its solubility:

  • Temperature: Increased temperature may enhance solubility in certain solvents.
  • pH Levels: Changes in pH might influence ionization and solubility, especially in biological systems.
  • Concentration: Higher concentrations can impact solubility dynamics as solute interactions increase.

Conclusion

In summary, the solubility of 2-[2-phenylethyl-[2-(propylcarbamoyloxy)ethyl]amino]ethyl N-propylcarbamate is a fascinating area of study, underscoring the compound's chemical behavior and potential applications. “Solubility is a key parameter that governs bioavailability and therapeutic efficacy.”

Interesting facts

Interesting Facts About 2-[2-phenylethyl-[2-(propylcarbamoyloxy)ethyl]amino]ethyl N-propylcarbamate

2-[2-phenylethyl-[2-(propylcarbamoyloxy)ethyl]amino]ethyl N-propylcarbamate is a fascinating compound with several noteworthy attributes:

  • Pharmacological Potential: This compound is often studied for its potential applications in medicine, particularly its role in developing novel pharmaceuticals that might target specific biological pathways.
  • Functional Groups: The presence of multiple functional groups, including the carbamate moiety, enhances its chemical reactivity and can significantly influence its interaction with biological systems.
  • Structure Activity Relationship (SAR): Researchers frequently investigate the structure-activity relationship of such compounds to understand how changes to molecular structure can affect their biological activities and therapeutic potential.
  • Synthesis Challenges: The synthesis of this compound may present challenges due to its complex structure, requiring advanced techniques in organic chemistry to manipulate its constituent parts successfully.
  • Insights into Neuropharmacology: Some derivatives of similar structure have been shown to interact with neurotransmitter systems, providing insight for developing treatments for neurodegenerative diseases.
  • Discovery of New Mechanisms: The exploration of this compound can pave the way for the discovery of new mechanisms of action, contributing to the overall body of knowledge in medicinal chemistry.

As scientists delve deeper into the unique characteristics and potential applications of 2-[2-phenylethyl-[2-(propylcarbamoyloxy)ethyl]amino]ethyl N-propylcarbamate, they remain optimistic about uncovering further secrets that could lead to innovative therapeutic strategies. The pursuit of understanding compounds like this highlights the excitement and challenges inherent in the field of chemical research!