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Naphazoline

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Identification
Molecular formula
C12H14N2
CAS number
835-31-4
IUPAC name
2-(2-phenylethyl)-4,5-dihydro-1H-imidazole
State
State

At room temperature, naphazoline is in a solid state, primarily observed as a crystalline powder. It is typically used in pharmaceutical preparations, where it may be dissolved for ease of administration.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
188.26g/mol
Molar mass
188.2600g/mol
Density
1.0900g/cm3
Appearence

Naphazoline is typically found as a clear, colorless, or nearly colorless crystalline powder. It may sometimes appear slightly yellowish-tinged due to impurities or exposure to air. The compound is often used in solutions where it remains transparent and does not impart any coloration to the preparation.

Comment on solubility

Solubility of 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole

The solubility of 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole can be quite intriguing due to its unique chemical structure and characteristics. Here are some essential points regarding its solubility:

  • Polar vs. Nonpolar: This compound has both polar and nonpolar characteristics, which can impact its solubility in different solvents.
  • Common Solvents: It tends to be soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), indicating moderate compatibility with polar solvents.
  • Water Solubility: However, its solubility in water is generally limited due to its hydrophobic phenylethyl group, which can hinder its interaction with polar water molecules.
  • Solubility Variations: Temperature and pH can significantly affect the solubility of this compound. Higher temperatures often enhance solubility, while variations in pH can lead to ionization or changes in solubility behavior.

In conclusion, while 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole exhibits interesting solubility characteristics in certain organic solvents, its overall solubility profile showcases the fascinating interplay between molecular structure and solvation phenomena.

Interesting facts

Exploring 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole

2-(2-phenylethyl)-4,5-dihydro-1H-imidazole is a fascinating compound that has caught the attention of both synthetic chemists and pharmacologists. Its unique structure and the presence of an imidazole ring make it a subject of interest in various research domains. Here are some interesting points about this compound:

  • Structure and Reactivity: The imidazole ring is known for its stability while being reactive enough to participate in a variety of chemical reactions. This feature allows chemists to modify its properties for different applications.
  • Biological Activity: Compounds containing imidazole structures are often linked to biological functions. They can act as crucial intermediates in the synthesis of pharmaceuticals, with potential effects on numerous biological pathways.
  • Pharmaceutical Applications: Due to its structural similarity to many biologically active molecules, derivatives of 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole may be explored for their therapeutic potential. Researchers are particularly interested in identifying compounds that could act as analgesics or anti-inflammatory agents.
  • Synthesis Methods: The synthesis of this compound can involve several different methods, often emphasizing the importance of a strategic approach to building complex structures in organic chemistry.
  • Dual Functionality: Its presence in drug discovery showcases the importance of dual functionality in molecules, meaning that compounds can potentially serve multiple purposes at once, enhancing their effectiveness in medicinal chemistry.

In summary, 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole represents a rich field of study, standing at the intersection of structural chemistry and pharmacology. Its diverse applications and the myriad of possible derivatives mark it as a **compound of significant interest** in contemporary research.

Synonyms
2-IMIDAZOLINE, 2-PHENETHYL-
Phenyzoline
26038-62-0
DTXSID30180682
RefChem:929090
DTXCID70103173
CHEMBL14210
2-(2-phenylethyl)-4,5-dihydro-1H-imidazole
beta-Phenylethylimidazoline
2-Phenethyl-2-imidazoline
1H-Imidazole, 4,5-dihydro-2-(2-phenylethyl)-
BRN 0129593
2-Phenethyl-4,5-dihydro-1H-imidazole
2-(beta-Phenylaethyl)imidazolin [German]
2-(beta-Phenylaethyl)imidazolin
5-23-07-00011 (Beilstein Handbook Reference)
SCHEMBL3172677
SCHEMBL4033870
SCHEMBL5352071
BDBM50138499
HS-3478
4,5-Dihydro-2-(2-phenylethyl)-1H-imidazole