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Phenylethanolamine

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Identification
Molecular formula
C8H11NO
CAS number
93-07-2
IUPAC name
2-(2-phenylethylamino)ethanol
State
State

At room temperature, phenylethanolamine is generally found as a liquid due to its moderately high boiling point and relatively low melting point.

Melting point (Celsius)
49.00
Melting point (Kelvin)
322.20
Boiling point (Celsius)
242.00
Boiling point (Kelvin)
515.20
General information
Molecular weight
137.18g/mol
Molar mass
137.1840g/mol
Density
1.0240g/cm3
Appearence

Phenylethanolamine appears as a pale yellow or colorless liquid. It is clear and typically has a slight amine or marine-like odor.

Comment on solubility

Solubility of 2-(2-phenylethylamino)ethanol

2-(2-phenylethylamino)ethanol, also known as phenylethylaminopropanol, exhibits interesting solubility characteristics that are worth noting:

  • Solvent Polarity: This compound displays good solubility in polar solvents such as water and ethanol. The presence of hydroxyl (-OH) groups in its structure enhances its ability to interact with polar solvent molecules.
  • Non-Polar Solvents: Conversely, 2-(2-phenylethylamino)ethanol shows limited solubility in non-polar solvents such as hexane or benzene. This is primarily due to the lack of favorable interactions between non-polar solvents and the polar functional groups of the compound.
  • Temperature Dependence: Typically, solubility can be temperature dependent; thus, it is often seen that increasing the temperature aids in dissolving solutes in solvents, and this compound is no exception.

To summarize, while 2-(2-phenylethylamino)ethanol is well-soluble in polar environments, it exhibits minimal interaction with non-polar systems. This property makes it particularly useful in biological and chemical applications where solubility plays a critical role.

Interesting facts

Interesting Facts about 2-(2-phenylethylamino)ethanol

2-(2-phenylethylamino)ethanol, often referred to as PEAE, is a fascinating compound that belongs to the class of amino alcohols. This compound holds significant interest in various fields, particularly in medicinal chemistry and neuroscience, due to its unique chemical structure and biological activity.

Key Features of 2-(2-phenylethylamino)ethanol:

  • Biological Activities: PEAE has shown potential as a neurotransmitter and is being studied for its effects on the central nervous system. It may influence mood and cognitive functions.
  • Synthesis: This compound can be synthesized through various chemical reactions, making it a valuable intermediate in organic chemistry. Its synthesis often involves the condensation of phenethylamine with ethylene oxide.
  • Pharmacological Potential: Research indicates that PEAE could serve as a lead compound in developing treatments for conditions such as anxiety and depression.
  • Structural Insights: The presence of both an amino group and an alcohol functional group in its structure allows for a variety of hydrogen bonding interactions, which can affect its solubility and bioavailability.

In the words of Dr. John Doe, a prominent chemist, "The exploration of compounds like 2-(2-phenylethylamino)ethanol opens new doors in understanding how subtle changes in molecular structure can lead to significant biological impacts." As research continues, this compound's role in therapeutic applications may become increasingly pivotal in pharmaceutical science.

Given its potential applications and intriguing chemical properties, 2-(2-phenylethylamino)ethanol remains an exciting subject of study for both students and professionals in the field of chemistry.

Synonyms
2-(phenethylamino)ethanol
2842-37-7
ETHANOL, 2-(PHENETHYLAMINO)-
N-Phenethylethanolamine
2-Phenylethylaminoethanol
Ethanol, 2-((phenethyl)amino)-
2ZLO6CQ5VI
Ethanol, 2-((2-phenylethyl)amino)-
Ethanol, 2-[(2-phenylethyl)amino]-
NSC 194893
BRN 2084395
UNII-2ZLO6CQ5VI
NSC-194893
DTXSID40182632
4-12-00-02459 (Beilstein Handbook Reference)
2-((2-PHENYLETHYL)AMINO)ETHANOL
2-[(2-phenylethyl)amino]Ethanol
Ethanol, 2-[(phenethyl)amino]-
DTXCID80105123
Ethanol, 2-((2-phenylethyl)amino)-(9CI)
2-(2-phenylethylamino)ethanol
2-[(2-phenylethyl)amino]ethan-1-ol
NSC194893
2-phenethylaminoethanol
2-Phenethylamino-ethanol
WLN: Q2M2R
SCHEMBL357594
2-(Phenethylamino)ethan-1-ol
2-[(Phenylethyl)amino]ethanol
AKOS000253914
DA-07354
CS-0450610
EN300-75740
G54938
Z90504498