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Terfenadine

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Identification
Molecular formula
C32H41NO2
CAS number
50679-08-8
IUPAC name
2-[(2-tert-butylphenyl)-phenyl-methoxy]-N,N-dimethyl-ethanamine
State
State

At room temperature, Terfenadine is a solid. It is usually encountered as a crystalline powder in pharmaceutical preparations.

Melting point (Celsius)
146.00
Melting point (Kelvin)
419.15
Boiling point (Celsius)
332.00
Boiling point (Kelvin)
605.15
General information
Molecular weight
471.69g/mol
Molar mass
471.6900g/mol
Density
1.2200g/cm3
Appearence

Terfenadine is typically in the form of a white powder. It is often provided in this solid form for use in pharmaceuticals.

Comment on solubility

Solubility of 2-[(2-tert-butylphenyl)-phenyl-methoxy]-N,N-dimethyl-ethanamine

The solubility of 2-[(2-tert-butylphenyl)-phenyl-methoxy]-N,N-dimethyl-ethanamine in various solvents can be influenced by multiple factors, including its molecular structure and functional groups. Here are some important points to consider:

  • Polar vs. Nonpolar Solvents: This compound is likely to exhibit greater solubility in nonpolar solvents due to the presence of bulky alkyl groups and aromatic rings that favor hydrophobic interactions.
  • Hydrophobic Interactions: The tert-butyl group and multiple aromatic components contribute to a strong hydrophobic character, which can hinder solubility in polar solvents like water.
  • Temperature Dependence: Solubility may increase with temperature, allowing for better solvation in certain organic solvents.
  • Functional Groups: The presence of the methoxy group can introduce a degree of polarity, but it may not be substantial enough to favor solubility in aqueous environments.

As a general observation, compounds similar in structure to 2-[(2-tert-butylphenyl)-phenyl-methoxy]-N,N-dimethyl-ethanamine are typically limited in their solubility in water, while demonstrating improved solubility in organic solvents such as ethanol or dichloromethane.

In summary, understanding the solubility profile of this compound involves recognizing the interplay between its chemical structure and the properties of the solvents. As always, experimental determination can provide the most accurate insights into solubility behavior.

Interesting facts

Interesting Facts about 2-[(2-tert-butylphenyl)-phenyl-methoxy]-N,N-dimethyl-ethanamine

This unique compound, often referred to in scientific literature by its systematic name, showcases a series of intriguing structural and functional characteristics that make it a subject of interest among chemists and researchers.

Key Characteristics

  • Amine Functionality: The presence of the N,N-dimethyl group indicates that this compound belongs to a class of compounds known as tertiary amines, which exhibit distinct properties, particularly in terms of their basicity and nucleophilicity.
  • Substituent Complexity: Featuring a tert-butyl group and a methoxy linkage, this compound showcases how steric hindrances and electronic effects can influence reactivity and stability, making it an excellent model for studying these interactions.
  • Potential Applications: Given the presence of various functional groups, this compound has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals or actives in agrochemicals.

Chemical Significance

The structure of this compound can lead to unique interactions with biological systems, making it a candidate for exploring novel therapeutic pathways. Its intricate arrangement allows for selective binding to certain receptors, which is a crucial aspect in drug design.

Research Perspectives

  • Exploration of its synthesis can provide insights into methodologies for creating complex organic compounds with high yields.
  • Studying its reactivity can unveil mechanisms that are applicable to a wider range of amine-based compounds.
  • Evaluation of its biological activity could contribute to the development of new compounds with enhanced efficacy and reduced side effects.

In summary, 2-[(2-tert-butylphenyl)-phenyl-methoxy]-N,N-dimethyl-ethanamine is not just a chemical entity; it is a gateway to numerous scientific inquiries and applications in chemistry, biology, and material sciences.

Synonyms
Bufenadrine
604-74-0
Bufenadrina
Bufenadrine [INN]
Bufenadrine, (-)-
M8E6NL8ES0
Bufenadrine, (+)-
B.S. 6534
2-[(2-tert-butylphenyl)-phenylmethoxy]-N,N-dimethylethanamine
UNII-M8E6NL8ES0
TZ26192UEK
9Y0T619B3U
BS 6534
Buphenadrin
Ethanamine, 2-((2-(1,1-dimethylethyl)phenyl)phenylmethoxy)-N,N-dimethyl-, (-)-
33431-12-8
Bufenadrinum
Ethanamine, 2-((2-(1,1-dimethylethyl)phenyl)phenylmethoxy)-N,N-dimethyl-, (+)-
33431-11-7
UNII-9Y0T619B3U
2-(o-tert-Butyl-alpha-phenylbenzyloxy)-N,N-dimethylethylamine; 2-tert-Butyldiphenhydramine
BUFENADINE
UNII-TZ26192UEK
2-(2-tert-Butylbenzhydryloxy)-N,N-dimethylethylamin
SCHEMBL2109428
CHEMBL2104614
DTXSID70862278
NS00124029
2-((o-tert-Butyl-alpha-phenyl-benzyl)oxy)-N,N-dimethylethylamine
2-((o-tert-Butyl-alpha-phenyl-benzyl)oxy)-N,N-dimethylethylamine.
2-((o-tert-Butyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine
2-((O-TERT-BUTYL-.ALPHA.-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINE
2-(o-tert-Butyl--phenylbenzyloxy)-N,N-dimethylethylamine; 2-tert-Butyldiphenhydramine