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Naphazoline

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Identification
Molecular formula
C14H14F3N2
CAS number
835-31-4
IUPAC name
2-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole
State
State

At room temperature, naphazoline is typically found in a solid state as a crystalline powder. When used pharmaceutically, it is often presented in liquid form, such as in eye drops.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.20
Boiling point (Celsius)
305.40
Boiling point (Kelvin)
578.50
General information
Molecular weight
246.27g/mol
Molar mass
246.2680g/mol
Density
1.3275g/cm3
Appearence

Naphazoline typically appears as a white to off-white crystalline powder. It is often provided in the form of ophthalmic solutions, where it is dissolved in water or saline to create a clear, colorless to slightly yellow solution.

Comment on solubility

Solubility of 2-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole

When considering the solubility of 2-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole, various factors come into play due to its complex structure. Here are some key points to note:

  • Aromatic Nature: The presence of the aromatic trifluoromethyl group significantly influences solubility. Aromatic compounds often exhibit low solubility in water but can dissolve in organic solvents.
  • Hydrophobic Interactions: The trifluoromethyl group contributes to hydrophobic characteristics, potentially reducing aqueous solubility.
  • Polarity Considerations: The imidazole portion of the molecule introduces some polar characteristics. This may aid in solubility in polar solvents but complicates the overall solvate ability.
  • Solvent Environment: Solubility can be enhanced in organic solvents such as ethanol or methanol, while it may be limited in water.

To summarize, while 2-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole may show some solubility in specific polar solvents, its overall solubility is subjected to the dominating influence of hydrophobic interactions due to the trifluoromethyl substituent. It is essential to conduct experimental studies to accurately assess solubility in various solvents.

Interesting facts

Interesting Facts about 2-[[2-(Trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole

This fascinating compound, commonly known as a critical building block in medicinal chemistry, boasts unique properties that are of great interest to scientists and researchers. Here are some compelling points about this intriguing molecule:

  • Fluorine in Pharmaceuticals: The presence of the trifluoromethyl group is notable. Fluorine substitution often enhances biological activity, making compounds more potent and selective in their interactions.
  • Diverse Applications: This imidazole derivative is versatile! It serves as a precursor in the synthesis of various pharmaceuticals and agrochemicals, showcasing its importance in both health and agriculture.
  • Structure-Activity Relationship (SAR): Understanding how modifications to the structure, such as the addition of the trifluoromethyl group, influence biological behavior is essential for drug design. This compound provides an excellent case study in SAR.
  • Heterocyclic Chemistry: As an imidazole, the compound belongs to a class of five-membered rings that are significant in organic chemistry. Heterocycles play key roles in many significant biological processes and are vital in the discovery of new drugs.
  • Research Potential: Scientists are continually exploring the properties of imidazole derivatives, with ongoing research focusing on their efficacy against various diseases, including cancer and infectious diseases.

An anonymous quote highlights its significance: "The innovations of today are the applications of tomorrow." As research advances, compounds like 2-[[2-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole stand at the forefront of discovery, paving the way for new therapeutic strategies.

In conclusion, this compound is not just a chemical entity; it's a gateway to enhancing our understanding of chemistry and its myriad applications in real-world problems.

Synonyms
2-IMIDAZOLINE, 2-(o-TRIFLUOROMETHYLBENZYL)-
3038-49-1
BRN 0915037
2-(o-Trifluoromethylbenzyl)-2-imidazoline
SCHEMBL954867
DTXSID10184461
BLGSIJYJOUMJMW-UHFFFAOYSA-N