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Pinacidil

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Identification
Molecular formula
C13H19N3O2
CAS number
60576-13-8
IUPAC name
2-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)guanidine
State
State

Pinacidil is typically a solid at room temperature. This compound is used in pharmaceutical applications and is often stored in a dry place to maintain its stability and efficacy.

Melting point (Celsius)
105.50
Melting point (Kelvin)
378.65
Boiling point (Celsius)
315.70
Boiling point (Kelvin)
588.85
General information
Molecular weight
252.31g/mol
Molar mass
252.2960g/mol
Density
1.1896g/cm3
Appearence

Pinacidil appears as a white to off-white crystalline powder. It is typically odorless and has a slightly bitter taste. The compound is often used in its hydrochloride form when applied in medicinal contexts.

Comment on solubility

Solubility of 2-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)guanidine

The solubility of 2-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)guanidine is a complex topic due to its unique molecular structure. Several factors influence the solubility behavior of this compound:

  • Polarity: The presence of the guanidine functional group suggests a degree of polarity, which can enhance solubility in polar solvents like water.
  • Hydrophobic and Hydrophilic Interactions: The benzodioxin moiety contributes hydrophobic characteristics, potentially limiting solubility in purely aqueous environments.
  • Temperature Dependency: As is common with many organic compounds, solubility may increase with temperature, resulting in higher dissolution rates at elevated temperatures.
  • pH Influence: The solubility can also be pH-dependent, particularly for guanidine derivatives, as ionization of the guanidine group may vary with the acidity or basicity of the solution.

In summary, while 2-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)guanidine may exhibit moderate solubility in water and various organic solvents, it is vital to consider the specific conditions, such as solvent type, temperature, and pH, to fully understand its solubility profile. A detailed analysis would be beneficial in predicting its behavior in different chemical environments.

Interesting facts

Interesting Facts about 2-(2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)guanidine

This intriguing compound, 2-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)guanidine, merges organic chemistry with medicinal potential, making it a subject of interest for many researchers. Here are some fascinating points about this compound:

  • Complex Structure: The molecule contains a unique dihydro-benzodioxin moiety, which is known for its biological activity.
  • Biological Interest: Compounds with a guanidine functional group are often studied for their potential in drug discovery, particularly in areas such as antitumor activity and antiviral effects.
  • Medicinal Chemistry: Researchers explore derivatives of guanidine for their ability to act as enzyme inhibitors. The presence of the benzodioxin ring may enhance the efficacy of such interactions.
  • Pharmacophore Elucidation: Understanding how the structure of this compound interacts with biological targets can pave the way for novel therapeutic approaches.
  • Potential Applications: Beyond medicinal uses, it may also find applications in materials science, acting as a precursor for specialized polymers or coatings.

In summary, 2-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)guanidine stands at the intersection of synthetic chemistry and biological science. Its multifaceted nature makes it a valuable candidate for further exploration in the development of new medications. As the scientific community continues to engage with such compounds, the potential discoveries are truly exciting to contemplate!

Synonyms
Guabenxan
19889-45-3
Guabenxane
Guabenxanum
SAW16W26X6
DTXSID60173643
(1,4-benzodioxan-6-yl-methyl)guanidine
DTXCID6096134
Guabenxan [INN:DCF]
2-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)guanidine
(1,4-Benzodioxan-6-ylmethyl)guanidine
Guabenxano
1-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methyl)guanidine
1-[(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methyl]guanidine
Guabenxane [INN-French]
Guabenxanum [INN-Latin]
Guabenxano [INN-Spanish]
UNII-SAW16W26X6
GUABENXAN [INN]
GUABENXAN [MART.]
GUABENXAN [WHO-DD]
2-(2,3-Dihydro-1,4-benzodioxin-7-ylmethyl)guanidine
SCHEMBL1172002
CHEMBL2105111
CHEBI:134872
MFCD00865971
SY340702
SY340703
1-[(1-Methyl-4-imidazolyl)methyl]guanidine
Q27289114