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Duloxetine

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Identification
Molecular formula
C12H20Cl2N2
CAS number
116539-59-4
IUPAC name
2-[(2,4-dichlorophenyl)methyl-prop-2-ynyl-amino]ethanol
State
State

At room temperature, Duloxetine is a solid.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
494.50
Boiling point (Kelvin)
767.70
General information
Molecular weight
297.16g/mol
Molar mass
297.1640g/mol
Density
1.2958g/cm3
Appearence

Duloxetine typically appears as an off-white to slightly brownish-white solid powder.

Comment on solubility

Solubility of 2-[(2,4-dichlorophenyl)methyl-prop-2-ynyl-amino]ethanol

The solubility of 2-[(2,4-dichlorophenyl)methyl-prop-2-ynyl-amino]ethanol can be influenced by various factors due to its unique structural properties. Generally, solubility refers to how well a compound can dissolve in a solvent, and in this case, both polar and non-polar characteristics should be considered.

Key Factors Influencing Solubility:

  • Polarity: The presence of the amino group (-NH2) suggests that the compound can interact favorably with polar solvents like water, enhancing its solubility.
  • Hydrophobic Regions: The 2,4-dichlorophenyl group introduces hydrophobic characteristics, which may limit solubility in polar solvents.
  • Sterics: The branched structure may create steric hindrance that affects how the molecule interacts with solvents.

To summarize, the solubility of this compound is likely to be moderate in polar solvents due to its amino group but is potentially limited by its hydrophobic parts. It may also exhibit variable solubility in organic solvents, making direct experimentation necessary for precise quantification. Understanding these factors can significantly enhance the formulation and application of this compound in chemical processes.

Interesting facts

Exploring 2-[(2,4-Dichlorophenyl)methyl-prop-2-ynyl-amino]ethanol

The compound 2-[(2,4-dichlorophenyl)methyl-prop-2-ynyl-amino]ethanol is an intriguing molecule with applications in various fields, notably in medicinal chemistry. Here are some interesting facts that highlight its significance:

  • Multi-functional Structure: This compound features a unique structure characterized by the presence of a dichlorophenyl group and a prop-2-ynyl amino unit, which contribute to its chemical versatility.
  • Potential Biological Activity: Compounds with similar structures have been investigated for their antimicrobial and antiviral properties. Researchers are particularly interested in how modifications to the amino group impact biological activity.
  • Synthetic Challenges: The synthesis of this compound can present challenges due to the need for selective reactions. Chemists often employ strategies such as functional group protection and orthogonal synthesis techniques to ensure successful product formation.
  • Environmental Considerations: The presence of chlorine in the structure prompts inquiries regarding environmental impact and toxicity. As such, researchers are keen on evaluating the compound's stability and breakdown products in various conditions.
  • Applications in Drug Design: Molecules similar to this compound are routinely used as lead compounds in drug discovery, providing a scaffold for modifications that can enhance efficacy and reduce side effects.
  • Interesting Reaction Pathways: The reactivity of the alkyne moiety in the structure can lead to unique chemical transformations, such as click chemistry reactions, which are pivotal in forming complex molecular architectures.

In summary, 2-[(2,4-dichlorophenyl)methyl-prop-2-ynyl-amino]ethanol encapsulates a fascinating blend of synthetic chemistry, biological relevance, and environmental awareness, making it a compound of great interest for ongoing research.

Synonyms
JYC13YO9F7
UNII-JYC13YO9F7
N-(2-Hydroxyethyl)-N-propargyl-2,4-dichlorobenzylamine
1211-52-5
2-(((2,4-Dichlorophenyl)methyl)-2-propynylamino)ethanol
Ethanol, 2-(((2,4-dichlorophenyl)methyl)-2-propyn-1-ylamino)-