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Iopamidol

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Identification
Molecular formula
C17H22I3N3O8
CAS number
60166-93-0
IUPAC name
2-[2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy]hexanoic acid
State
State

At room temperature, Iopamidol is typically a solid, appearing as a crystalline powder. Its solubility in water makes it suitable for use as a contrast medium in various radiological examinations.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
777.09g/mol
Molar mass
777.0860g/mol
Density
2.2580g/cm3
Appearence

Iopamidol generally appears as a white or off-white crystalline powder. It is synthesized as a non-ionic, water-soluble iodinated contrast agent often used in medical imaging.

Comment on solubility

Solubility of 2-[2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy]hexanoic acid

2-[2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy]hexanoic acid is a compound that presents some intriguing characteristics regarding its solubility.

Generally speaking, the solubility of a compound can be influenced by several factors, such as:

  • Polarity: The presence of polar functional groups often enhances solubility in polar solvents like water.
  • Hydrogen Bonding: Molecules capable of strong hydrogen bonding typically show increased solubility in polar solvents.
  • Temperature: Solubility may increase with temperature; thus, the conditions under which the compound is dissolved can vary widely.

In the case of 2-[2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy]hexanoic acid, its structure contains multiple polar groups that could suggest reasonable solubility in some solvents. However, the presence of the bulky triiodo substituent and lipophilic hexanoic acid chain may hinder its easy dissolution:

  • The presence of iodine atoms introduces greater molecular weight and alters the polarity.
  • The chain length of the hexanoic acid could lead to limited solubility in highly polar solvents.

Moreover, a compound's solubility is often described in qualitative terms. Solubility can generally be classified as:

  • Soluble: Freely dissolves in a solvent.
  • Partly Soluble: Dissolves to a certain extent but may leave undissolved residues.
  • Insoluble: Little to no dissolution in a given solvent.

Given the factors above, one could speculate that 2-[2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy]hexanoic acid may exhibit limited solubility characteristics, especially in water, but further experimentation and context-dependent studies would be essential to draw conclusive insights.

Interesting facts

Interesting Facts About 2-[2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy]hexanoic Acid

2-[2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy]hexanoic acid is a fascinating compound with unique chemical properties and applications. Here are some remarkable insights about this intriguing compound:

  • Structural Complexity: This compound features a highly intricate structure with multiple functional groups, including several iodine atoms and a phenoxy moiety. The presence of iodine significantly influences the compound's biological and chemical properties.
  • Medical Applications: Due to its triiodo substituents, this compound could have applications in the field of medicinal chemistry, particularly in drug design and development. Iodinated compounds are often investigated for their potential as imaging agents in medical diagnostics.
  • Biochemical Activity: The methylcarbamoyl groups contribute to the compound's interactions with biological systems, potential enzymatic inhibition, and its role in pharmacology. Such structural components often enhance bioavailability and target specificity.
  • Environmental Behavior: Compounds with iodine applications have implications in environmental studies as they can partake in various biochemical cycles. Understanding their stability and breakdown in ecosystems can provide insights into their ecological impact.
  • Historical Context: The synthesis and study of iodine-containing compounds date back to the dawn of organic chemistry. Their unique properties made them a subject of interest in research and industrial applications, as evidenced in studies from the early 20th century.
  • Future Research: As researchers continue to explore the potential of novel compounds, 2-[2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy]hexanoic acid could open pathways to new discoveries in chemistry, material science, and bioengineering.

As a representative of its class, this compound is not only a testament to the creativity of chemists but also an example of how intricate molecular designs can lead to groundbreaking advancements in science.