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Diclofenac

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Identification
Molecular formula
C14H11Cl2NO2
CAS number
15307-86-5
IUPAC name
2-(2,5-dichloro-4-cyclohexyl-phenyl)acetic acid
State
State

At room temperature, diclofenac is typically in a solid state. It is commonly found in crystalline powder form and is often used as a salt in pharmaceutical formulations to increase its solubility and bioavailability.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
327.00
Boiling point (Kelvin)
600.15
General information
Molecular weight
318.14g/mol
Molar mass
318.1360g/mol
Density
1.5040g/cm3
Appearence

Diclofenac appears as a white to slightly yellow crystalline powder. It is practically insoluble in water, which gives it a distinct texture in its solid form. The crystalline nature is visually evident under magnification, displaying sharp-edged crystals.

Comment on solubility

Solubility of 2-(2,5-dichloro-4-cyclohexyl-phenyl)acetic acid

The solubility of 2-(2,5-dichloro-4-cyclohexyl-phenyl)acetic acid in various solvents reveals important characteristics that can influence its applications in pharmaceuticals and chemical reactions. Key aspects of its solubility include:

  • Solvent Dependence: The solubility of this compound is significantly influenced by the polarity of the solvent. Generally, polar solvents such as water may show limited solubility due to hydrophobic interactions.
  • Organic Solvents: It tends to exhibit better solubility in organic solvents like ethanol, methanol, and acetone, where its aromatic and aliphatic structures can engage in favorable interactions.
  • pH Effects: The solubility can also vary with pH due to the compound's acidic nature. In basic conditions, the deprotonation can enhance solubility in aqueous solutions.

In practical terms, it is essential to consider the following when working with this compound:

  1. For biological applications, analyzing its solubility in physiological conditions helps predict its bioavailability.
  2. During synthetic processes, selecting the appropriate solvent can ensure better reactant dispersion and reaction outcomes.
  3. Understanding solubility behavior can facilitate effective formulation strategies in drug development.

As a general guideline, when working with 2-(2,5-dichloro-4-cyclohexyl-phenyl)acetic acid, one might find that the compound is sparingly soluble in water but displays appreciable solubility in non-polar and mildly polar organic solvents, making it versatile for various applications.

Interesting facts

Exploring 2-(2,5-Dichloro-4-cyclohexyl-phenyl)acetic Acid

2-(2,5-Dichloro-4-cyclohexyl-phenyl)acetic acid is a fascinating compound that belongs to the category of organic acids, specifically carboxylic acids. Its structure features a cyclohexyl group and two chlorine atoms substituted on the aromatic phenyl ring, which contributes to its unique properties and potential applications.

Key Characteristics:

  • Versatile Applications: This compound has shown promise in various fields, including pharmaceuticals, where it can serve as an intermediate in the synthesis of biologically active molecules.
  • Chlorine Influence: The presence of chlorine atoms significantly influences the compound's reactivity and biological properties, often enhancing its function as a bioactive agent.
  • Cyclohexyl Substitution: The cyclohexyl group contributes to steric bulk, which can impact molecular interactions, potentially affecting its pharmacodynamics.

One of the remarkable aspects of 2-(2,5-Dichloro-4-cyclohexyl-phenyl)acetic acid is its potential for targeted therapies. As scientists delve deeper into its mechanism of action, they are discovering how its unique structure can be harnessed to design more effective drugs with fewer side effects.

In the lab, chemists are equally intrigued by its synthesis. The pathways to create this compound often involve intricate organic reactions, showcasing the beauty of creativity in chemical synthesis. As noted by renowned chemists, “The art of synthesis lies in the subtle balance of reactivity and selectivity.” This philosophy rings true when working with complex compounds like 2-(2,5-Dichloro-4-cyclohexyl-phenyl)acetic acid.

Furthermore, ongoing research into this compound reflects the dynamic nature of chemistry, as scientists constantly seek to uncover new properties and potential uses. This area of study exemplifies the excitement and challenges present in the field of chemistry!

Synonyms
TAI 278
(2,5-Dichloro-4-cyclohexylphenyl)acetic acid
Benzeneacetic acid, 2,5-dichloro-4-cyclohexyl-
ACETIC ACID, (2,5-DICHLORO-4-CYCLOHEXYLPHENYL)-
DTXSID50928260
DTXCID501357031
13376-40-4
2-(2,5-dichloro-4-cyclohexylphenyl)acetic acid
2,5-Dichloro-4-cyclohexylphenylacetic acid