Skip to main content

Nicardipine

ADVERTISEMENT
Identification
Molecular formula
C26H29ClN2O5
CAS number
54527-84-3
IUPAC name
[2-[(2,6-dichlorophenyl)carbamoyloxy]cyclohexyl]-diethyl-ammonium;chloride
State
State

At room temperature, nicardipine hydrochloride is typically a solid.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.15
General information
Molecular weight
515.27g/mol
Molar mass
515.2700g/mol
Density
1.3000g/cm3
Appearence

Nicardipine hydrochloride appears as a white to off-white crystalline powder that is practically odorless.

Comment on solubility

Solubility of [2-[(2,6-dichlorophenyl)carbamoyloxy]cyclohexyl]-diethyl-ammonium;chloride

The solubility of the compound [2-[(2,6-dichlorophenyl)carbamoyloxy]cyclohexyl]-diethyl-ammonium;chloride] can be influenced by several factors due to its complex structure. Generally, ammonium salts tend to display good solubility in water, which is pertinent for this compound. Here are some key points to consider:

  • Polarity: The presence of the ammonium group typically increases polarity, enhancing solubility in aqueous solutions.
  • Chloride Ion Contribution: The chloride ion is known to contribute to the solubility of salts in water, allowing for the ionic dissociation.
  • Organic Solvents: Given the organic moieties present in the compound, it may exhibit varied solubility in organic solvents like ethanol or acetone.
  • pH Dependence: The solubility can also vary with pH changes, affecting the ionization state of the compound.

In conclusion, while the compound is expected to be soluble in water owing to its ionic character, its solubility profile in organic solvents may warrant further investigation. As a result, one could summarize the solubility characteristics as:

"A balance between polar and non-polar characteristics defines the solubility landscape of this compound."
Interesting facts

Interesting Facts about 2-[(2,6-Dichlorophenyl)carbamoyloxy]cyclohexyl-diethyl-ammonium Chloride

This fascinating compound belongs to a class of chemical agents known for their diverse applications in various fields, particularly in medicinal chemistry and agricultural sciences. Its unique structure makes it a subject of significant interest:

  • Pharmaceutical Potential: Compounds like this are often studied for their potential use as therapeutic agents. The presence of the carbamoyloxy group is particularly interesting as it may influence binding affinity to biological targets.
  • Agricultural Applications: This compound might also have applications in agrochemicals. Certain derivatives have been known to act as effective herbicides or fungicides, showcasing how synthetic chemistry can aid in sustainable agriculture.
  • Synthetic Pathways: The synthesis of this compound poses intriguing challenges. Chemists often explore multiple reaction conditions and catalysts to achieve optimal yields and purity. The reaction mechanisms involved can provide deep insights into chemical reactivity and stability.
  • Structure-Activity Relationship (SAR): Understanding SAR is critical in drug development. The variations in substituents, like the 2,6-dichlorophenyl group, can significantly alter the compound's biological properties and activity—paving the way for personalized medicine approaches.
  • Safety and Toxicology: As with all chemical compounds, safety assessments are essential, especially for those with potential biological activity. Studies are conducted to evaluate toxicity profiles and environmental impact, ensuring responsible usage.

As we explore this compound, it becomes a vivid example of chemical creativity. The ability to design molecules with tailored properties opens doors to innovations that can lead to practical solutions in medicine and agriculture.

In summary, the study of 2-[(2,6-dichlorophenyl)carbamoyloxy]cyclohexyl-diethyl-ammonium chloride not only highlights the versatility of organic synthesis but also serves as a reminder of the intricate relationship between chemical structure and function in the realm of applied sciences.

Synonyms
2-(Diethylamino)cyclohexyl 2,6-dichlorocarbanilate hydrochloride
20186-51-0
K 1201
2,6-Dichlorocarbanilic acid 2-(diethylamino)cyclohexyl ester hydrochloride
CARBANILIC ACID, 2,6-DICHLORO-, 2-(DIETHYLAMINO)CYCLOHEXYL ESTER, HYDROCHLORIDE