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Clonidine

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Identification
Molecular formula
C10H12Cl2N2O
CAS number
4205-90-7
IUPAC name
2-[(2,6-dichlorophenyl)methoxy]guanidine
State
State

At room temperature, clonidine is a solid.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
412.90
Boiling point (Kelvin)
686.05
General information
Molecular weight
266.12g/mol
Molar mass
266.1490g/mol
Density
1.3400g/cm3
Appearence

Clonidine is typically found as a white to off-white powder. It is practically odorless and may come in the form of tablets when used pharmaceutically.

Comment on solubility

Solubility of 2-[(2,6-dichlorophenyl)methoxy]guanidine

The solubility of 2-[(2,6-dichlorophenyl)methoxy]guanidine can be intriguing due to its unique structure. Understanding its solubility characteristics is vital for various applications in pharmaceuticals and chemical research. Here are some key points regarding the solubility of this compound:

  • Polarity: The presence of the guanidine and methoxy functional groups suggests that the compound might exhibit moderate polarity, affecting its solubility in different solvents.
  • Solvent Sensitivity: It is essential to consider which type of solvent is used, as solubility can change drastically between:
    • Polar solvents: such as water, where the polar functional groups can interact favorably.
    • Non-polar solvents: which may not solvate the compound effectively due to its structure.
  • Temperature Dependence: Like many compounds, the solubility of 2-[(2,6-dichlorophenyl)methoxy]guanidine may increase with temperature, which is a common phenomenon observed in chemical compounds.

In practice, the solubility data for this compound might vary, making it essential to conduct experiments under controlled conditions to ascertain specific solubility metrics. For a more comprehensive understanding, researchers should conduct solubility assessments in various solvents and temperatures to define its behavior effectively.

Interesting facts

Interesting Facts About 2-[(2,6-Dichlorophenyl)methoxy]guanidine

2-[(2,6-Dichlorophenyl)methoxy]guanidine is a fascinating compound that has garnered significant attention in the field of medicinal chemistry due to its potential therapeutic applications. Below are some compelling aspects of this unique molecular entity:

  • Pharmacological Potential: Research indicates that this compound may exhibit properties beneficial for treating various medical conditions, particularly in the realm of antidiabetic and antihypertensive therapies.
  • Structural Significance: The presence of the 2,6-dichlorophenyl group enhances the pharmacological profile of this molecule, contributing to increased biological activity by modifying how the compound interacts with biological targets.
  • Synthetic Routes: The synthesis of 2-[(2,6-dichlorophenyl)methoxy]guanidine showcases the elegant interplay between organic synthesis techniques and modern medicinal chemistry. Its synthesis often involves multiple steps to construct the guanidine moiety effectively.
  • Reactivity and Stability: Understanding the reactivity of this compound is crucial, as it plays a key role in its stability and biological efficacy. This necessitates careful study of its chemical behavior under various conditions.
  • Biological Mechanisms: Early studies suggest that 2-[(2,6-dichlorophenyl)methoxy]guanidine may function through multiple biological pathways, which presents an intriguing area for further investigation. It may influence metabolic pathways, enhancing insulin sensitivity or altering vascular responses.

As researchers continue to explore this compound, it becomes clear that 2-[(2,6-dichlorophenyl)methoxy]guanidine represents a promising avenue for further study, potentially leading to improved therapeutic options in the future. The bridge between its chemical structure and biological function exemplifies the elegance of chemistry in understanding and combating disease.