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Ro 5-3450

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Identification
Molecular formula
C8H9Cl2N3
CAS number
46063-91-8
IUPAC name
2-[(2,6-dichlorophenyl)methyleneamino]guanidine
State
State

At room temperature, this compound is typically in a solid state.

Melting point (Celsius)
204.50
Melting point (Kelvin)
477.65
Boiling point (Celsius)
412.50
Boiling point (Kelvin)
685.65
General information
Molecular weight
219.08g/mol
Molar mass
219.0780g/mol
Density
1.5600g/cm3
Appearence

The compound typically appears as a colorless or white crystalline solid.

Comment on solubility

Solubility of 2-[(2,6-dichlorophenyl)methyleneamino]guanidine (C8H9Cl2N3)

The solubility of 2-[(2,6-dichlorophenyl)methyleneamino]guanidine presents some interesting characteristics that highlight its chemical behavior in various solvents. Here are some key points regarding its solubility:

  • Polar Solvents: Generally, compounds containing guanidine groups exhibit increased solubility in polar solvents due to hydrogen bonding.
  • Apolar Solvents: In contrast, this compound may have reduced solubility in nonpolar solvents, primarily because of its chlorinated phenyl group which tends to favor interactions with more polar environments.
  • Solubility Dependence: Its solubility can be highly dependent on factors such as temperature and pH of the solution. Higher temperatures typically enhance solubility.
  • Self-Association: The presence of the guanidine moiety may also lead to self-association in solution, potentially influencing the effective concentration of the compound.

In summary, while 2-[(2,6-dichlorophenyl)methyleneamino]guanidine shows favorable solubility characteristics in polar solvents, it is imperative to consider the specific conditions of the solution for comprehensive insights into its solubility behavior. Always remember, "The key to solubility lies in the interactions between solute and solvent!"

Interesting facts

Interesting Facts about 2-[(2,6-dichlorophenyl)methyleneamino]guanidine

The compound 2-[(2,6-dichlorophenyl)methyleneamino]guanidine, often referred to in the context of its potential applications in medicinal chemistry, offers a fascinating glimpse into the world of organic compounds. Here are some engaging facts that highlight its significance:

  • Antibiotic Research: This compound has drawn attention for its potential applications as an antibacterial agent, offering a promising route for the development of new treatments against resistant strains of bacteria.
  • Structure-Activity Relationship: The unique structural features of 2-[(2,6-dichlorophenyl)methyleneamino]guanidine make it an appealing subject for studying how molecular modifications can influence biological activity and potency.
  • Chlorine Atoms: The presence of two chlorine atoms in its structure can significantly enhance its biological activity, owing to the lipophilic nature of chlorine which may improve the compound's ability to penetrate cell membranes.
  • Academic Interest: Many researchers in the fields of medicinal chemistry and pharmacology are delving into compounds like this one to explore new therapeutic avenues, emphasizing the importance of interdisciplinary research.
  • Guanidine Derivatives: Being a guanidine derivative, this compound could potentially exhibit nitrogen-rich chemistry, which is crucial for various biological processes and pharmaceutical developments.

This compound serves as a reminder of the intricate relationship between chemical structure and biological function in the quest for novel pharmaceuticals. As one researcher aptly noted, "The journey of understanding a compound begins with not just its composition but its potential to transform lives."

Continuing to study such compounds enriches our knowledge and expands the horizons of what is possible in drug discovery and development.

Synonyms
5051-62-7
2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
Spectrum_000843
Prestwick0_000096
Prestwick1_000096
Spectrum2_001114
Spectrum3_000445
Spectrum4_000567
Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, (E)-
KBioGR_000974
KBioSS_001323
2-[(2,6-dichlorophenyl)methylideneamino]guanidine
DivK1c_000010
SPBio_001248
SPBio_001991
CHEMBL1313657
KBio1_000010
KBio2_001323
KBio2_003891
KBio2_006459
KBio3_001310
NINDS_000010
WDZVGELJXXEGPV-UHFFFAOYSA-N
HMS2233D12
HMS3370A17
BCP30851
AKOS017264577
DB00629
2,6-dichlorobenzaldehyde guanylhydrazone
MRF-0000008
DB-051784
NS00006873
Guanabenzum;WY-8678; WY 8678; WY8678
N-(2,6-dichlorobenzylidene)-N'-amidino hydrazine
SR-01000721838
SR-01000721838-5
Q27164730