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Nabumetone

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Identification
Molecular formula
C9H9NO4S
CAS number
42924-53-8
IUPAC name
2-[[2,6-dimethyl-4-[[2-(o-tolyl)acetyl]amino]phenyl]sulfonylamino]acetic acid
State
State
At room temperature, Nabumetone is in a solid state. It is commonly prepared in tablet form for pharmaceutical use.
Melting point (Celsius)
80.00
Melting point (Kelvin)
353.15
Boiling point (Celsius)
579.00
Boiling point (Kelvin)
852.15
General information
Molecular weight
228.25g/mol
Molar mass
228.2470g/mol
Density
1.4400g/cm3
Appearence

Nabumetone generally appears as a white to off-white crystalline powder. It is generally odorless.

Comment on solubility

Solubility of 2-[[2,6-dimethyl-4-[[2-(o-tolyl)acetyl]amino]phenyl]sulfonylamino]acetic acid

The solubility of 2-[[2,6-dimethyl-4-[[2-(o-tolyl)acetyl]amino]phenyl]sulfonylamino]acetic acid (C9H9NO4S) is influenced by its complex molecular structure and the presence of functional groups.

Key considerations regarding its solubility include:

  • Polarity: The presence of polar functional groups, such as the sulfonamide and carboxylic acid, suggests that this compound may have some degree of solubility in polar solvents, particularly water.
  • Solvent Compatibility: Due to its hydrophilic nature provided by these groups, it may exhibit higher solubility in solvents like methanol and ethanol, than in non-polar solvents.
  • pH Influence: The solubility might also be significantly affected by the pH of the solution, with increased solubility in basic conditions where the carboxylic acid group could deprotonate.
  • Temperature Effects: An increase in temperature generally enhances solubility for most organic compounds, so this could be beneficial for dissolving this compound.

In summary, while the intricate structure of this compound presents challenges in predicting solubility, it is likely to be more soluble in polar solvents, with increasing temperature and favorable pH conditions enhancing its dissolution characteristics. As always, experimental solubility testing is recommended to obtain precise data for practical applications.

Interesting facts

Interesting Facts about 2-[[2,6-dimethyl-4-[[2-(o-tolyl)acetyl]amino]phenyl]sulfonylamino]acetic acid

The compound 2-[[2,6-dimethyl-4-[[2-(o-tolyl)acetyl]amino]phenyl]sulfonylamino]acetic acid is a fascinating example of a sulfonamide, which is a class of compounds that have wide-ranging applications in medicinal chemistry.

Key Highlights:

  • Sulfonamide Structure: The sulfonamide group in this compound contributes to its biological activity, making it relevant in various pharmacological applications.
  • Medicinal Significance: Compounds like this one have been studied for their potential as antibacterial agents, illustrating how modifications in their structure can influence therapeutic effects.
  • Biological Activity: The presence of the acetylamino group provides intriguing possibilities for enzyme inhibition, which is critical in developing new drugs.
  • Structure-Activity Relationship: Researchers often investigate how substitutions on the aromatic rings influence the efficacy and selectivity of the compound, emphasizing the importance of chemical modifications.

This compound's intricate architecture is a testament to the ingenuity of organic chemistry. As scientists continue to explore its properties, it holds promise for new discoveries in medicinal chemistry and beyond. The ability to tweak certain functional groups opens up a pathway for synthesizing novel compounds with enhanced activities.

In the words of a famous chemist: “Chemistry is the art of failure. But it is also the art of possibilities.” Such compounds encapsulate this notion by representing both the challenges and opportunities inherent in the field of chemical research.

Furthermore, understanding the mechanisms through which these compounds function at the molecular level can pave the way for innovative therapeutic strategies, showcasing the significance of such studies in advancing healthcare.

Synonyms
INHIBITOR IDD 384
CHEMBL240719
[2,6-dimethyl-4-(2-o-tolyl-acetylamino)-benzenesulfonyl]-glycine
I84
2-(2,6-dimethyl-4-(2-(2-methylphenyl)acetamido)benzenesulfonamido)acetic acid
2-{2,6-dimethyl-4-[2-(2-methylphenyl)acetamido]benzenesulfonamido}acetic acid
BDBM50222612
DB01689
NS00068861
Q27092865
2-(2,6-dimethyl-4-(2-o-tolylacetamido)phenylsulfonamido)acetic acid
N-[(2,6-dimethyl-4-{[(2-methylphenyl)acetyl]amino}phenyl)sulfonyl]glycine