Skip to main content

Thiamine pyrophosphate

ADVERTISEMENT
Identification
Molecular formula
C12H19N4O7P2
CAS number
154-87-0
IUPAC name
2-[[[(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyethyl-trimethyl-ammonium
State
State

At room temperature, thiamine pyrophosphate is typically a solid.

Melting point (Celsius)
100.00
Melting point (Kelvin)
373.15
Boiling point (Celsius)
175.00
Boiling point (Kelvin)
448.15
General information
Molecular weight
466.36g/mol
Molar mass
466.3590g/mol
Density
1.1800g/cm3
Appearence

Thiamine pyrophosphate, also known as thiamine diphosphate, is a white to off-white crystalline powder. It is hygroscopic, meaning it tends to absorb moisture from the air.

Comment on solubility

Solubility of 2-[[[(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyethyl-trimethyl-ammonium

The solubility of the compound 2-[[[(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyethyl-trimethyl-ammonium can be described as notably complex due to its intricate structure and the presence of multiple functional groups. The solubility characteristics can typically be influenced by:

  • Polarity: The presence of numerous hydroxyl (-OH) and amino (-NH2) groups suggests that the compound may exhibit high polarity, thus enhancing its solubility in polar solvents, particularly water.
  • Ionic nature: As a quaternary ammonium compound, it may possess positive charges which can interact favorably with water molecules, potentially leading to increased solubility.
  • Hydrogen bonding: The capacity for hydrogen bonding, prompted by hydroxyl and amino groups, can facilitate the solvation process, further enhancing solubility in aqueous environments.

Considering these factors, this compound is expected to be:

  • Highly soluble in water, due to the interactions mentioned above.
  • Less soluble in organic solvents that are non-polar, due to a lack of compatible interaction.

In conclusion, while solubility can vary based on concentration and environmental conditions, the compound is anticipated to exhibit significant aqueous solubility, positioning it favorably for applications where water solubility is a vital consideration.

Interesting facts

Interesting Facts about 2-[[[(2R,3S,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyethyl-trimethyl-ammonium

This compound is part of a fascinating class of molecules known for their biological significance, especially in the field of pharmacology and biochemistry. Here are some captivating points:

  • Biological Role: This compound is often studied for its potential role as a nucleotide analogue, which means it can mimic the natural building blocks of nucleic acids. This characteristic makes it an attractive candidate for developing antiviral and anticancer therapies.
  • Structure Complexity: The intricate structure includes multiple functional groups such as amino, hydroxy, and phosphoryl modifications. This complexity is crucial because it enhances the compound's interaction with biological targets, influencing its efficacy.
  • Stability: The presence of a tetrahydrofuran ring in the structure contributes to its stability and solubility in biological systems, making it an excellent candidate for drug formulation.
  • Mechanism of Action: As a potential therapeutic agent, the compound may interfere with essential biological processes by inhibiting enzymes responsible for nucleic acid synthesis, showcasing its potential in treating various diseases.
  • Research Applications: Scientists and researchers are continuously exploring this compound's ability to modify gene expression, which could lead to breakthroughs in gene therapy and regenerative medicine.

In summary, the compound is a prime example of how complex organic molecules can have profound implications in medical science. As research progresses, we may uncover even more exciting applications in the treatment of diseases.

Overall, the exploration of this compound not only highlights the intricacies of chemistry but also showcases the potential for innovation in drug development and therapeutics.

Synonyms
CDP-choline(1+)
Nicolin
Citifar
Corenalin
Hornbest
Neucolis
Sintoclar
Somazine
Reagin
Rexort
Audes
Emicholine F
CDP-choline (1+)
cytidine-5' diphosphocholine
SCHEMBL8303928
CHEBI:49086
Cytidine 5-diphosphate-trihydrogen
s5362
cytidine-5'-pyrophosphate-hydroxycholine
PD063018
P-hydroxide[2-(trimethylammonio)ethyl] ester
Q421308
BRD-A91728607-001-01-8
BRD-A91728607-236-11-9
5'-O-[hydroxy({hydroxy[2-(trimethylammonio)ethoxy]phosphoryl}oxy)phosphoryl]cytidine
2-(((((((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-N,N,N-trimethylethan-1-aminium