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Fluocinolone acetonide phosphate

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Identification
Molecular formula
C24H30FO8P
CAS number
79250-74-7
IUPAC name
[2-[(2S,4R,8S,11S,12R)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] hydrogen phosphate
State
State
At room temperature, Fluocinolone acetonide phosphate is typically a solid. It is stable under normal conditions and is widely used in pharmaceutical formulations.
Melting point (Celsius)
286.00
Melting point (Kelvin)
559.15
Boiling point (Celsius)
354.00
Boiling point (Kelvin)
627.15
General information
Molecular weight
494.48g/mol
Molar mass
494.4760g/mol
Density
1.3500g/cm3
Appearence

Fluocinolone acetonide phosphate appears as a white to off-white crystalline powder with no distinctive odor. It is typically available in a pure and refined form used in the production of pharmaceutical products.

Comment on solubility

Solubility of [2-[(2S,4R,8S,11S,12R)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] hydrogen phosphate

The solubility of the compound [2-[(2S,4R,8S,11S,12R)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] hydrogen phosphate is an intriguing aspect to consider due to its complex structure. Here are some key points regarding its solubility:

  • Hydrophilicity vs. Hydrophobicity: The presence of the phosphate group suggests a potential for high hydrophilicity, which usually enhances solubility in polar solvents such as water.
  • Structural Complexity: The multi-ring structure may introduce steric hindrance, which could affect how well it interacts with solvent molecules.
  • Polarity Considerations: The balance between polar functional groups and hydrophobic segments will play a critical role in determining its solubility profile.
  • Common Solvents: Typically, compounds with such characteristics may show improved solubility in solvents like methanol or ethanol compared to non-polar organic solvents.

In summary, studying the solubility of this compound requires a careful evaluation of its structural features, potential interactions with solvents, and the degree of flexibility within its framework. Given these aspects, one can expect variability in solubility based on temperature, pH, and the nature of the solvent used.

Interesting facts

Interesting Facts about 2-[(2S,4R,8S,11S,12R)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] Hydrogen Phosphate

This compound, a remarkable member of the phosphoric acid derivatives, showcases the fascinating intersection of organic chemistry and biochemistry. Here are some key points about this unique molecule:

  • Complex Structure: The compound features a complex architecture known as pentacyclo[10.8.0.02,9.04,8.013,18]icosa, which is characteristic of natural products with significant biological activity.
  • Biological Significance: Compounds such as this one are often synthesized for their potential therapeutic properties, particularly in relation to enzyme inhibitors or intermediates in metabolic pathways.
  • Fluorination: The presence of a fluorine atom in its structure enhances its properties, potentially influencing the pharmacokinetics of the compound, making it more suitable for medicinal applications.
  • Hydrophilicity vs. Lipophilicity: The balance between the hydrophilic phosphate group and the hydrophobic hydrocarbon framework plays a crucial role in its behavior in biological systems, impacting drug delivery and bioavailability.

The synthesis and exploration of such complex molecules inspire chemists to delve into structural modifications, aiming to enhance efficacy and minimize side effects. As one researcher stated, "Nature often provides us with the most intricate designs; our role is to unlock their potential." The ongoing study of this compound may not only unveil its biological roles but also contribute to the broader field of medicinal chemistry.