Skip to main content

Fluocinolone acetonide acetate

ADVERTISEMENT
Identification
Molecular formula
C27H33FO7
CAS number
66734-13-4
IUPAC name
[2-[(2S,4R,8S,11S,12R)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] acetate
State
State

At room temperature, fluocinolone acetonide acetate exists in a solid state, appearing as a crystalline powder. Being solid at room temperature makes it relatively easy to handle and store compared to liquid or gaseous forms of similar compounds.

Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
465.20
Boiling point (Kelvin)
738.35
General information
Molecular weight
452.50g/mol
Molar mass
452.5030g/mol
Density
1.2700g/cm3
Appearence

Fluocinolone acetonide acetate typically appears as a fine, white to off-white crystalline powder. While its crystalline form is the most commonly encountered, variations in texture and granularity can occur depending on the manufacturing process. It may exhibit a relative humidity-dependent stability in its solid state.

Comment on solubility

Solubility of 2-[(2S,4R,8S,11S,12R)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl acetate

The solubility of this complex compound, featuring multiple functional groups and a unique polycyclic structure, is greatly influenced by its molecular characteristics. Understanding its solubility profile is crucial for both its practical applications and further research. Here are some key points regarding its solubility:

  • Polarity: Due to the presence of various polar functional groups such as the acetate moiety and hydroxyl groups, the compound may exhibit considerable solubility in polar solvents like water and alcohols.
  • Hydrophobic interactions: The polycyclic structure and numerous methyl groups contribute to hydrophobic character, potentially decreasing solubility in water while enhancing solubility in organic solvents, especially those with non-polar characteristics.
  • Conformational aspects: The specific three-dimensional arrangement of atoms (stereochemistry) may also affect how well the compound interacts with solvents, possibly leading to unique solubility behaviors.
  • Temperature dependence: Like many organic compounds, solubility can vary with temperature; an increase in temperature may increase solubility in certain solvents.

Overall, while the compound may display variable solubility based on solvent choice and environmental conditions, it is anticipated that its intricate structure will lead to noticeable differences in solubility behavior among various solvents. Further empirical studies would be essential to clarify its solubility in practical scenarios.

Interesting facts

Interesting Facts about 2-[(2S,4R,8S,11S,12R)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] acetate

This intriguing compound, known for its complex structure and unique properties, belongs to the category of natural products that exhibit significant biological activity. Here are a few compelling facts that highlight its importance:

  • Complex Structure: The compound features a highly intricate carbon skeleton, consisting of multiple fused rings. This kind of structure often leads to diverse chemical reactivity and can facilitate various interactions in biological systems.
  • Biological Significance: Compounds similar to this one have been studied for their potential medicinal properties, particularly in areas such as anti-cancer and anti-inflammatory research. The unique functional groups, including the fluorine and hydroxy groups, may enhance its biological activity.
  • Synthetic Challenges: The synthesis of this type of compound is often challenging due to its multiple stereocenters and functional groups. Chemists frequently engage in *asymmetric synthesis* techniques to construct such compounds efficiently.
  • Applications in Drug Design: The structure of this compound serves as a valuable template for the design of new pharmaceuticals. Researchers can modify various parts of the molecule to tailor its properties for specific therapeutic targets.
  • Environmental Impact: Understanding the interactions and transformations of this compound in the environment is crucial for assessing its potential ecological effects, especially if it is used in agricultural applications.

Overall, 2-[(2S,4R,8S,11S,12R)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] acetate exemplifies the fascinating intersection of chemistry and biology, prompting ongoing research and exploration in various scientific fields.

Synonyms
AKOS015914135
E80429
2-[(2S,4R,8S,11S,12R)-12-FLUORO-11-HYDROXY-6,6,9,13-TETRAMETHYL-16-OXO-5,7-DIOXAPENTACYCLO[10.8.0.0(2),?.0?,?.0(1)(3),(1)?]ICOSA-14,17-DIEN-8-YL]-2-OXOETHYL ACETATE