Skip to main content

Clonidine

ADVERTISEMENT
Identification
Molecular formula
C9H9Cl2N3
CAS number
4205-91-8
IUPAC name
2-[3-(2,6-dichlorophenyl)propylamino]guanidine
State
State

Clonidine is typically found as a solid at room temperature.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
469.15
Boiling point (Kelvin)
742.30
General information
Molecular weight
229.10g/mol
Molar mass
229.1050g/mol
Density
1.4300g/cm3
Appearence

Clonidine appears as a white to off-white crystalline powder. It is highly soluble in water and ethanol, allowing for various pharmaceutical formulations. The powder may appear odorless or have a very slight characteristic odor.

Comment on solubility

Solubility of 2-[3-(2,6-Dichlorophenyl)propylamino]guanidine

The solubility characteristics of 2-[3-(2,6-dichlorophenyl)propylamino]guanidine can be quite fascinating, reflecting its chemical structure and interactions with solvents. Here are several key points to consider:

  • Solvent Compatibility: This compound's solubility often varies significantly between polar and non-polar solvents. Generally, guanidine derivatives like this one tend to exhibit better solubility in polar solvents due to the presence of guanidine functional groups.
  • Temperature Effect: The solubility might increase with temperature, as is common for many organic compounds. Higher temperatures can disrupt solute-solvent interactions, increasing dissolution.
  • pH Influence: Changes in pH can impact the solubility of 2-[3-(2,6-dichlorophenyl)propylamino]guanidine significantly. In more acidic or basic environments, the protonation or deprotonation of the amino groups may enhance solubility.
  • Crystalline Nature: If the compound forms crystalline structures, the solubility may be lower due to a higher lattice energy that must be overcome during dissolution.

In summary, while 2-[3-(2,6-dichlorophenyl)propylamino]guanidine can be soluble in specific conditions, its behavior is largely influenced by solvent polarity, temperature, and the surrounding pH. Understanding these parameters is essential for applications in pharmaceutical formulations and chemical syntheses.

Interesting facts

Interesting Facts about 2-[3-(2,6-dichlorophenyl)propylamino]guanidine

2-[3-(2,6-dichlorophenyl)propylamino]guanidine is a fascinating compound largely studied in the field of medicinal chemistry. Its intriguing structure and properties have garnered interest for various applications, especially in pharmacology.

Key Characteristics

  • Biological Activity: This compound is recognized for its potential as a pharmacological agent, particularly in the treatment of certain diseases, including hypertension.
  • Structure-Activity Relationship: The 2,6-dichlorophenyl group enhances lipophilicity, which can affect how the compound interacts with biological membranes.
  • Mechanism of Action: It engages in interactions that may modulate specific receptor pathways, making it an interesting candidate for drug development.

Research and Development

Ongoing research has focused on optimizing its efficacy and safety profile. Various studies have explored:

  • The synthesis methods to enhance yields and purity.
  • Developing derivatives with improved pharmacological properties.
  • Investigating its interactions at the molecular level through advanced techniques like crystal structure analysis.

Additionally, scientists often cite this compound for its role in elucidating complex biochemical pathways, aiding in the understanding of how certain drugs impact human health. Notably, one researcher noted, “The unique characteristics of 2-[3-(2,6-dichlorophenyl)propylamino]guanidine continue to push the boundaries of therapeutic possibilities.”

In summary, 2-[3-(2,6-dichlorophenyl)propylamino]guanidine is more than just a chemical formula—it represents a bridge between chemistry and real-world medical applications, embodying the intricate balance of structure and function in drug design.

Synonyms
BRN 0750703
29096-66-0
GUANIDINE, (3-(2,6-DICHLOROPHENYL)PROPYL)AMINO-
(3-(2,6-Dichlorophenyl)propyl)aminoguanidine
DTXSID40183341
RefChem:346753
DTXCID50105832