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Fentanyl

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Identification
Molecular formula
C22H28N2O
CAS number
437-38-7
IUPAC name
2-[3-(3-hydroxyphenyl)-2,3-dimethyl-1-piperidyl]-1-phenyl-ethanone
State
State

At room temperature, fentanyl is typically found as a white solid, either in powder form or as part of a transdermal patch for medical use. It can also be formulated as a liquid injection for medical use.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
600.00
Boiling point (Kelvin)
873.00
General information
Molecular weight
336.47g/mol
Molar mass
336.4710g/mol
Density
1.2255g/cm3
Appearence

Fentanyl is typically a white to off-white powder. In its pharmaceutical form, it may also be available as a clear, colorless, or slightly yellow solution when used in injections. Illicitly manufactured fentanyl can vary in appearance but is often found as a white or slightly off-white powder.

Comment on solubility

Solubility of 2-[3-(3-hydroxyphenyl)-2,3-dimethyl-1-piperidyl]-1-phenyl-ethanone

The solubility of 2-[3-(3-hydroxyphenyl)-2,3-dimethyl-1-piperidyl]-1-phenyl-ethanone can be considered within the context of its chemical structure and functional groups present. Here are some observations relevant to its solubility:

  • Polarity: The presence of the hydroxyl group (-OH) suggests that the compound may exhibit moderate polar characteristics, potentially allowing it to interact with polar solvents such as water to some extent.
  • Hydrophobic Components: The phenyl and piperidine rings contribute to hydrophobicity, which could limit solubility in polar solvents but may enhance solubility in nonpolar organic solvents.
  • Temperature Dependence: Solubility can be temperature-dependent; higher temperatures may facilitate greater dissolution in certain solvents, owing to increased molecular motion.
  • Solvent Interaction: The solubility may greatly vary between solvents, with favorable solubility predicted in organic solvents like ethanol and dichloromethane compared to water.
  • Derivatives and pH: The presence of –NH and –OH groups may influence solubility in relation to pH, leading to better solubility in slightly acidic or basic conditions where ionization may occur.

Overall, while the compound may show a predilection towards solubility in certain organic solvents, precise solubility data would necessitate empirical testing to accurately define its behavior across a range of conditions and environments.

Interesting facts

2-[3-(3-hydroxyphenyl)-2,3-dimethyl-1-piperidyl]-1-phenyl-ethanone: An In-Depth Look

This compound, known for its intriguing structural complexity, belongs to a class of organic compounds often studied in medicinal chemistry. Here are some fascinating aspects of 2-[3-(3-hydroxyphenyl)-2,3-dimethyl-1-piperidyl]-1-phenyl-ethanone:

  • Pharmacological Interest: This compound is studied for its potential pharmacological uses, particularly in the realm of neuroscience. Its unique functional groups may enable it to interact with specific neurotransmitter systems.
  • Structural Diversity: The presence of the piperidine ring makes this compound structurally interesting. Piperidines are known for their versatility and are often found in various pharmacologically active compounds.
  • Hydroxyphenyl Group: The 3-hydroxyphenyl substituent can significantly affect the compound's bioactivity. This hydroxyl group can participate in hydrogen bonding, enhancing interactions with biological targets.
  • Dimethyl Substituents: The dimethyl groups on the piperidine contribute to steric hindrance, which may influence the molecule’s selectivity and activity at its biological targets.
  • Analytical Studies: Because of its complex structure, various chromatographic techniques are often employed to analyze and purify this compound, making it a great example for students learning about compound synthesis and characterization.

As scientists continue to explore compounds like 2-[3-(3-hydroxyphenyl)-2,3-dimethyl-1-piperidyl]-1-phenyl-ethanone, they uncover the potential for novel therapeutic applications. This compound serves not only as a fascinating subject in research but also offers insights into how even subtle changes in molecular structure can lead to significant changes in biological activity. As one researcher aptly stated, “The beauty of chemistry lies in the details of molecular design, where every atom counts.”

Synonyms
Myfadol
4575-34-2
Mifadol
Myfadol [INN]
Myfadolum
Mifadol [INN-Spanish]
Myfadolum [INN-Latin]
UNII-MON17C96OK
MON17C96OK
TA 306
2-(3-(3-Hydroxyphenyl)-2,3-dimethylpiperidino)acetophenon
2-(3-(m-Hydroxyphenyl)-2,3-dimethylpiperidino)acetophenone
Mifadol (INN-Spanish)
Myfadolum (INN-Latin)
ACETOPHENONE, 2-(3-(M-HYDROXYPHENYL)-2,3-DIMETHYLPIPERIDINO)-
ETHANONE, 2-(3-(3-HYDROXYPHENYL)-2,3-DIMETHYL-1-PIPERIDINYL)-1-PHENYL-
2-[3-(3-hydroxyphenyl)-2,3-dimethylpiperidin-1-yl]-1-phenylethanone
SCHEMBL1134718
CHEMBL2105184
DTXSID40863419
NS00126662
Q27284146
2-[3-(3-Hydroxyphenyl)-2,3-dimethylpiperidin-1-yl]-1-phenylethan-1-one