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Ipidacrine

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Identification
Molecular formula
C13H22N4
CAS number
62772-39-8
IUPAC name
2-[3-(3-methyl-1-piperidyl)propyl]guanidine
State
State

At room temperature, ipidacrine is in a solid state, appearing as a crystalline powder. It is stable under standard conditions and doesn't easily absorb moisture from the air, maintaining its solid form.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
334.30
Boiling point (Kelvin)
607.45
General information
Molecular weight
257.34g/mol
Molar mass
257.3960g/mol
Density
1.0450g/cm3
Appearence

Ipidacrine typically appears as a white to off-white crystalline powder. It is known for its high purity and fine particulate texture, making it easily manipulable for various pharmaceutical applications.

Comment on solubility

Solubility of 2-[3-(3-methyl-1-piperidyl)propyl]guanidine

Understanding the solubility of 2-[3-(3-methyl-1-piperidyl)propyl]guanidine is essential for its applications in various chemical and pharmacological contexts. The solubility of this compound can be influenced by several factors:

  • Polarity: As a guanidine derivative, it possesses polar functional groups, which can enhance its solubility in polar solvents.
  • Hydrogen Bonding: The presence of amino groups in the structure allows for potential hydrogen bonding with water molecules, further contributing to solubility.
  • Chain Length: The branched alkyl structure provided by the 3-methyl-1-piperidyl group affects the solubility. Shorter alkyl chains often improve solubility in aqueous solutions.
  • pH Influence: Its solubility may increase in acidic or basic environments depending on the protonation states of the nitrogen atoms involved.

Generally, one might expect that 2-[3-(3-methyl-1-piperidyl)propyl]guanidine would demonstrate reasonable solubility in water due to its polar attributes. However, quantitative solubility data is essential to fully characterize its behavior in different solvents. In summary, while the structural characteristics of this guanidine derivative suggest favorable solubility, testing in various conditions will yield the most accurate and comprehensive understanding.

Interesting facts

Interesting Facts about 2-[3-(3-methyl-1-piperidyl)propyl]guanidine

2-[3-(3-methyl-1-piperidyl)propyl]guanidine is a fascinating chemical compound with various implications in both medicinal chemistry and pharmacology. Here are some insightful aspects of this compound:

  • Pharmacological Profile: This compound may exhibit a range of biological activities, particularly as a potential candidate for the treatment of various diseases involving the serotonergic and adrenergic systems.
  • Structural Features: The presence of a guanidine group offers unique reactivity and interaction capabilities with biological targets. It provides an opportunity for researchers to explore its role in enzyme inhibition and receptor modulation.
  • Potential Therapeutic Applications: Researchers are investigating its applications in areas such as pain management, depression, and neurodegenerative diseases. The piperidine ring contributes to its ability to cross biological membranes, affecting its bioavailability.
  • Structure-Activity Relationship (SAR): The structure of this compound provides an excellent basis for SAR studies. Modifying the piperidine ring structure or the guanidine moiety could lead to enhanced efficacy or reduced side effects in medicinal applications.
  • Research and Development: Given its complex structure, ongoing research into this compound has the potential to unearth novel insights into drug design, demonstrating how small changes can influence pharmacological outcomes.

As with many chemical compounds in medicinal chemistry, 2-[3-(3-methyl-1-piperidyl)propyl]guanidine showcases the vast possibilities that arise from understanding molecular architecture and its implications in human health. The continuing exploration of its properties will surely reveal more about its potential in therapeutic contexts.